Cytogenetic data from CP-CML patients with −Y in Ph+ cells at diagnosis
No. . | Sex . | Age at diagnosis, y . | −Y in addition to the t(9;22)(q34;q11) or the variant t(v;22) at diagnosis [no. of analyzed metaphases] . |
---|---|---|---|
1 | M | 48 | 45,X,−Y,t(9;22)(q34;q11)[13]/46,XY[12] |
2 | M | 50 | 45,X,−Y,t(9;22)(q34;q11)[23]/46,XY[2] |
3 | M | 44 | 45,X,−Y,t(9;22)(q34;q11)[5]/46,XY[6] |
4 | M | 40 | 45,X,−Y,t(9;22)(q34;q11)[20] |
5 | M | 56 | 45,X,−Y,t(9;22)(q34;q11)[3]/46,XY[22] |
6 | M | 65 | 45,X,−Y,t(9;22)(q34;q11)[20] |
7 | M | 42 | 45,X,−Y,t(9;22)(q34;q11)[13]/46,XY[7] |
8 | M | 70 | 45,X,−Y,t(9;22)(q34;q11)[25] |
9 | M | 59 | 45,X,−Y,t(9;22)(q34;q11)[25] |
10 | M | 58 | 45,X,−Y,t(9;22)(q34;q11)[25] |
11 | M | 74 | 45,X,−Y,t(9;22)(q34;q11)[14]/46,XY[11] |
12 | M | 70 | 45,X,−Y,t(9;22)(q34;q11)[12]/46,XY[5] |
13 | M | 75 | 45,X,−Y,t(9;22)(q34;q11)[20] |
14 | M | 81 | 45,X,−Y,t(9;22)(q34;q11)[15] |
15 | M | 32 | 45,X,−Y,t(9;22)(q34;q11)[17]/46,XY[8] |
16 | M | 68 | 45,X,−Y,t(9;22)(q34;q11)[18]/46,XY[2] |
17 | M | 60 | 45,X,−Y,t(9;22)(q34;q11)[15] |
18 | M | 66 | 45,X,−Y,t(9;22)(q34;q11)[18] |
19 | M | 66 | 45,X,−Y,t(9;22)(q34;q11)[3]/46,XY[22] |
20 | M | 63 | 45,X,−Y,t(9;22)(q34;q11)[4]/46,XY[16] |
21 | M | 62 | 45,X,−Y,t(9;22)(q34;q11)[6]/46,XY[14] |
22 | M | 62 | 45,X,−Y,t(9;22)(q34;q11)[6]/46,XY[19] |
23 | M | 30 | 45,X,−Y,t(9;22)(q34;q11)[7]/46,XY[15] |
24 | M | 61 | 45,X,−Y,t(9;22)(q34;q11)[19]/46,XY[5] |
25 | M | 79 | 45,X,−Y,t(9;22)(q34;q11)[17]/46,XY[3] |
26 | M | 67 | 45,X,−Y,t(9;22)(q34;q11)[16] |
27 | M | 67 | 45,X,−Y,t(2;9;22)(p13;q34;q11)[20] |
28 | M | 62 | 45,X,−Y,t(9;22)(q34;q11)[20] |
29 | M | 56 | 45,X,−Y,t(9;22)(q34;q11)[30] |
30 | M | 52 | 45,X,−Y,t(9;22)(q34;q11)[7] |
31 | M | 61 | 45,X,−Y,t(9;22)(q34;q11)[20] |
32 | M | 72 | 45,X,−Y,t(9;22)(q34;q11)[14] |
33 | M | 68 | 45,X,−Y,t(9;22)(q34;q11)[25] |
34 | M | 67 | 45,X,−Y,t(9;22)(q34;q11)[25] |
35 | M | 73 | 45,X,−Y,t(9;22)(q34;q11)[25] |
36 | M | 78 | 45,X,−Y,t(9;22)(q34;q11)[15] |
37 | M | 61 | 45,X,−Y,t(9;22)(q34;q11)[20] |
38 | M | 66 | 45,X,−Y,t(9;22)(q34;q11)[25] |
No. . | Sex . | Age at diagnosis, y . | −Y in addition to the t(9;22)(q34;q11) or the variant t(v;22) at diagnosis [no. of analyzed metaphases] . |
---|---|---|---|
1 | M | 48 | 45,X,−Y,t(9;22)(q34;q11)[13]/46,XY[12] |
2 | M | 50 | 45,X,−Y,t(9;22)(q34;q11)[23]/46,XY[2] |
3 | M | 44 | 45,X,−Y,t(9;22)(q34;q11)[5]/46,XY[6] |
4 | M | 40 | 45,X,−Y,t(9;22)(q34;q11)[20] |
5 | M | 56 | 45,X,−Y,t(9;22)(q34;q11)[3]/46,XY[22] |
6 | M | 65 | 45,X,−Y,t(9;22)(q34;q11)[20] |
7 | M | 42 | 45,X,−Y,t(9;22)(q34;q11)[13]/46,XY[7] |
8 | M | 70 | 45,X,−Y,t(9;22)(q34;q11)[25] |
9 | M | 59 | 45,X,−Y,t(9;22)(q34;q11)[25] |
10 | M | 58 | 45,X,−Y,t(9;22)(q34;q11)[25] |
11 | M | 74 | 45,X,−Y,t(9;22)(q34;q11)[14]/46,XY[11] |
12 | M | 70 | 45,X,−Y,t(9;22)(q34;q11)[12]/46,XY[5] |
13 | M | 75 | 45,X,−Y,t(9;22)(q34;q11)[20] |
14 | M | 81 | 45,X,−Y,t(9;22)(q34;q11)[15] |
15 | M | 32 | 45,X,−Y,t(9;22)(q34;q11)[17]/46,XY[8] |
16 | M | 68 | 45,X,−Y,t(9;22)(q34;q11)[18]/46,XY[2] |
17 | M | 60 | 45,X,−Y,t(9;22)(q34;q11)[15] |
18 | M | 66 | 45,X,−Y,t(9;22)(q34;q11)[18] |
19 | M | 66 | 45,X,−Y,t(9;22)(q34;q11)[3]/46,XY[22] |
20 | M | 63 | 45,X,−Y,t(9;22)(q34;q11)[4]/46,XY[16] |
21 | M | 62 | 45,X,−Y,t(9;22)(q34;q11)[6]/46,XY[14] |
22 | M | 62 | 45,X,−Y,t(9;22)(q34;q11)[6]/46,XY[19] |
23 | M | 30 | 45,X,−Y,t(9;22)(q34;q11)[7]/46,XY[15] |
24 | M | 61 | 45,X,−Y,t(9;22)(q34;q11)[19]/46,XY[5] |
25 | M | 79 | 45,X,−Y,t(9;22)(q34;q11)[17]/46,XY[3] |
26 | M | 67 | 45,X,−Y,t(9;22)(q34;q11)[16] |
27 | M | 67 | 45,X,−Y,t(2;9;22)(p13;q34;q11)[20] |
28 | M | 62 | 45,X,−Y,t(9;22)(q34;q11)[20] |
29 | M | 56 | 45,X,−Y,t(9;22)(q34;q11)[30] |
30 | M | 52 | 45,X,−Y,t(9;22)(q34;q11)[7] |
31 | M | 61 | 45,X,−Y,t(9;22)(q34;q11)[20] |
32 | M | 72 | 45,X,−Y,t(9;22)(q34;q11)[14] |
33 | M | 68 | 45,X,−Y,t(9;22)(q34;q11)[25] |
34 | M | 67 | 45,X,−Y,t(9;22)(q34;q11)[25] |
35 | M | 73 | 45,X,−Y,t(9;22)(q34;q11)[25] |
36 | M | 78 | 45,X,−Y,t(9;22)(q34;q11)[15] |
37 | M | 61 | 45,X,−Y,t(9;22)(q34;q11)[20] |
38 | M | 66 | 45,X,−Y,t(9;22)(q34;q11)[25] |
All patients show −Y in addition to the translocation t(9;22)(q34;q11) or to a variant translocation (patient 27); patients 1-28 show no metaphases with −Y under CR (karyotypes 46,XY), whereas patients 29-38 show cells without t(9;22)(q34;q11) in CR but with −Y (45,X,−Y). Cytogenetic analyses were made and interpreted according to ISCN 2009.29
No. indicates number of patients; M, male; and CP, chronic phase.