Detection of platelet-specific gene expression in thrombocytes by transcriptional profiling
Human gene . | Log2 ratio (T/L) . | P . |
---|---|---|
MPL | 8.72 | < .001 |
GP9 | 9.80 | < .001 |
ITGB3 | 9.25 | < .001 |
ITGB1 | 1.13 | .002 |
ITGA6 | 2.37 | .004 |
ITGA2 | 7.75 | < .001 |
ITGAV | 4.60 | < .001 |
F2R | 4.72 | .001 |
F2RL3 | 2.80 | .007 |
P2RX1 | 9.67 | < .001 |
P2RY1 | 3.91 | < .001 |
P2RY12 | 0 | .58 |
HTR2A | 8.86 | < .001 |
CD36 | 10.01 | < .001 |
TBXAS1 | 6.22 | < .001 |
GP1BA | 8.99 | < .001 |
Human gene . | Log2 ratio (T/L) . | P . |
---|---|---|
MPL | 8.72 | < .001 |
GP9 | 9.80 | < .001 |
ITGB3 | 9.25 | < .001 |
ITGB1 | 1.13 | .002 |
ITGA6 | 2.37 | .004 |
ITGA2 | 7.75 | < .001 |
ITGAV | 4.60 | < .001 |
F2R | 4.72 | .001 |
F2RL3 | 2.80 | .007 |
P2RX1 | 9.67 | < .001 |
P2RY1 | 3.91 | < .001 |
P2RY12 | 0 | .58 |
HTR2A | 8.86 | < .001 |
CD36 | 10.01 | < .001 |
TBXAS1 | 6.22 | < .001 |
GP1BA | 8.99 | < .001 |
Thrombocytes and lymphocytes were sorted by positive and negative selection for cell-specific markers, and gene expression analysis was performed by use of the Affymetrix chicken gene chip. The log2 of the gene expression ratio of thrombocytes vs lymphocytes (T L) and P values for genes of known platelet function are shown. All gene names used are those approved by the HUGO gene nomenclature committee (HGNC). F2R and F2RL3 refer to PAR1 and PAR3, respectively.