Relative expression of nucleoside transporters hENT1, hENT2, and hCNT3 in patient samples
Patient ID . | Best response . | Expression relative to normal PBMCs, 2−ΔΔCt (range) . | ||
---|---|---|---|---|
hENT1 . | hENT2 . | hCNT3 . | ||
39 | PR | 0.019 (0.014-0.025) | 0.03 (0.02-0.04) | 0.067 (0.42-0.1) |
42 | NE | 0.056 (0.044-0.072) | 0.009 (0.005-0.017) | N/E |
45 | SD | 9.91 (7.04-13.96) | 0.14 (0.03-0.065) | 2.42 (0.25-23.67) |
50 (baseline) | PR | 0.10 (0.09-0.12) | 0.67 (0.3-1.5) | 0.063 (0.01-0.33) |
At relapse | 0.43 (0.28-0.65) | 0.23 (0.15-0.37) | 0.98 (0.15-6.5) | |
Normal PBMCs | 1.00 (0.76-1.32) | 1.00 (0.66-1.5) | 1.00 (0.22-4.47) |
Patient ID . | Best response . | Expression relative to normal PBMCs, 2−ΔΔCt (range) . | ||
---|---|---|---|---|
hENT1 . | hENT2 . | hCNT3 . | ||
39 | PR | 0.019 (0.014-0.025) | 0.03 (0.02-0.04) | 0.067 (0.42-0.1) |
42 | NE | 0.056 (0.044-0.072) | 0.009 (0.005-0.017) | N/E |
45 | SD | 9.91 (7.04-13.96) | 0.14 (0.03-0.065) | 2.42 (0.25-23.67) |
50 (baseline) | PR | 0.10 (0.09-0.12) | 0.67 (0.3-1.5) | 0.063 (0.01-0.33) |
At relapse | 0.43 (0.28-0.65) | 0.23 (0.15-0.37) | 0.98 (0.15-6.5) | |
Normal PBMCs | 1.00 (0.76-1.32) | 1.00 (0.66-1.5) | 1.00 (0.22-4.47) |
hENT indicates human equilibrative nucleoside transporter; PR, partial remission; NE, not evaluable, N/E, not expressed; and SD, stable disease.