Table 3 Major bleeding and thrombosis at... | American Society of Hematology

Table 3

Major bleeding and thrombosis at the time of diagnosis and during follow-up

	At time of diagnosis						During follow-up
	All patients (n = 101)		Propositi (n = 67)		Relatives (n = 34)		All patients (n = 101)		Propositi (n = 67)		Relatives (n = 34)
	No.	%	No.	%	No.	%	No.	%	No.	%	No.	%
Major bleeding	11	10.9	9	13.4	2	5.9	2	2.0	2	3.0	0	0
Critical area*	3	3.0	3	4.5	0	0	0	0	0	0	0	0
Requiring blood or fibrinogen transfusion	6	5.9	4	6.0	2	5.9	2	2.0	2	3.0	0	0
Requiring surgery intervention	2	2.0	2	3.0	0	0	0	0	0	0	0	0
Total thrombosis†	14	13.9	11	16.4	3	8.8	14	13.8	11	16.4	3	12.5
Venous thrombosis	10	9.9	7	10.5	3	8.8	11	10.9	9	13.4	2	5.9
Deep venous thrombosis	8	7.9	6	9.0	2	5.9	3	3.0	2	3.0	1	2.9
Provoked	0	0	0	0	0	0	2	2.0	1	1.6	1	2.9
Recurrent	3	3.0	2	3.0	1	3.0	1	1.0	0	0	1	2.9
PE	2	2.0	1	1.5	1	2.9	2	2.0	2	3.0	0	0
Provoked	1	1.0	1	1.5	0	0	2	2.0	2	3.0	0	0
Superficial thrombophlebitis	0	0	0	0	0	0	2	2.0	2	3.0	0	0
Other‡	0	0	0	0	0	0	4	4.0	3	4.5	1	2.9
Recurrent	0	0	0	0	0	0	1	1.0	1	1.6	0	0
Arterial thrombosis	4	4.0	4	6.0	0	0	6	5.9	4	6.4	2	5.9
Stroke	3	3.0	3	4.5	0	0	2	2.0	1	1.6	1	2.9
Acute myocardial infarction	1	1.0	1	1.5	0	0	2	2.0	1	1.6	1	2.9
Recurrent	0	0	0	0	0	0	2	2.0	1	1.6	1	2.9
Peripheral thrombosis	0	0	0	0	0	0	1	1.0	1	1.6	0	0
Recurrent	0	0	0	0	0	0	1	1.0	1	1.6	0	0
Other§	0	0	0	0	0	0	1	1.0	1	1.6	0	0

	At time of diagnosis						During follow-up
	All patients (n = 101)		Propositi (n = 67)		Relatives (n = 34)		All patients (n = 101)		Propositi (n = 67)		Relatives (n = 34)
	No.	%	No.	%	No.	%	No.	%	No.	%	No.	%
Major bleeding	11	10.9	9	13.4	2	5.9	2	2.0	2	3.0	0	0
Critical area*	3	3.0	3	4.5	0	0	0	0	0	0	0	0
Requiring blood or fibrinogen transfusion	6	5.9	4	6.0	2	5.9	2	2.0	2	3.0	0	0
Requiring surgery intervention	2	2.0	2	3.0	0	0	0	0	0	0	0	0
Total thrombosis†	14	13.9	11	16.4	3	8.8	14	13.8	11	16.4	3	12.5
Venous thrombosis	10	9.9	7	10.5	3	8.8	11	10.9	9	13.4	2	5.9
Deep venous thrombosis	8	7.9	6	9.0	2	5.9	3	3.0	2	3.0	1	2.9
Provoked	0	0	0	0	0	0	2	2.0	1	1.6	1	2.9
Recurrent	3	3.0	2	3.0	1	3.0	1	1.0	0	0	1	2.9
PE	2	2.0	1	1.5	1	2.9	2	2.0	2	3.0	0	0
Provoked	1	1.0	1	1.5	0	0	2	2.0	2	3.0	0	0
Superficial thrombophlebitis	0	0	0	0	0	0	2	2.0	2	3.0	0	0
Other‡	0	0	0	0	0	0	4	4.0	3	4.5	1	2.9
Recurrent	0	0	0	0	0	0	1	1.0	1	1.6	0	0
Arterial thrombosis	4	4.0	4	6.0	0	0	6	5.9	4	6.4	2	5.9
Stroke	3	3.0	3	4.5	0	0	2	2.0	1	1.6	1	2.9
Acute myocardial infarction	1	1.0	1	1.5	0	0	2	2.0	1	1.6	1	2.9
Recurrent	0	0	0	0	0	0	2	2.0	1	1.6	1	2.9
Peripheral thrombosis	0	0	0	0	0	0	1	1.0	1	1.6	0	0
Recurrent	0	0	0	0	0	0	1	1.0	1	1.6	0	0
Other§	0	0	0	0	0	0	1	1.0	1	1.6	0	0

Retroperitoneal, n = 1; intracranial, n = 2.

Total of first arterial or venous thrombosis; 3 patients had both arterial and venous thromboses.

Three splanchnic and 1 retinal thrombosis.

Mesenteric artery thrombosis.