Table 5

Multivariate analysis of risk factors for obstetrical complications

Miscarriage or still birth (n = 27/111 pregnancies)Postpartum hemorrhage* (n = 19/89 pregnancies)
No.%OR†95% CIPNo.%OR†95% CIP
Relatives 2/24 8.3 1.0 (ref)   5/23 21.7 1.0 (ref)   
Propositi 25/87 28.7 3.6 0.8-15.7 .09 14/66 21.2 0.7 0.2-3.0 .65 
No bleeding phenotype 17/54 31.5 1.0 (ref)   3/39 7.7 1.0 (ref)   
Bleeding phenotype 10/57 17.5 0.4 0.1-1.0 .05 16/34 32.0 5.8 1.2-28.0 .03 
Nonhotspot mutations 15/48 31.3 1.0 (ref)   11/36 30.6 1.0 (ref)   
FGA Arg35 mutation 3/15 12.0 0.6 0.1-3.3 .60 1/12 8.3 0.3 0.1-2.4 .24 
FGG Arg301 mutation 9/48 18.8 0.6 0.2-1.6 .29 7/41 17.1 0.6 0.1-2.2 .39 
Miscarriage or still birth (n = 27/111 pregnancies)Postpartum hemorrhage* (n = 19/89 pregnancies)
No.%OR†95% CIPNo.%OR†95% CIP
Relatives 2/24 8.3 1.0 (ref)   5/23 21.7 1.0 (ref)   
Propositi 25/87 28.7 3.6 0.8-15.7 .09 14/66 21.2 0.7 0.2-3.0 .65 
No bleeding phenotype 17/54 31.5 1.0 (ref)   3/39 7.7 1.0 (ref)   
Bleeding phenotype 10/57 17.5 0.4 0.1-1.0 .05 16/34 32.0 5.8 1.2-28.0 .03 
Nonhotspot mutations 15/48 31.3 1.0 (ref)   11/36 30.6 1.0 (ref)   
FGA Arg35 mutation 3/15 12.0 0.6 0.1-3.3 .60 1/12 8.3 0.3 0.1-2.4 .24 
FGG Arg301 mutation 9/48 18.8 0.6 0.2-1.6 .29 7/41 17.1 0.6 0.1-2.2 .39 
*

Adjusted for age (at pregnancy) and parity.

†

Among live and still births.

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