Table 3

Cytogenetic abnormalities and molecular features of ALK+ vs ALK− ALCL

ALK+ ALCLALK- ALCL
Recurrent translocations involving ALK Recurrent translocations involving DUSP22:IRF4 
t(2;5)(p23;25) ALK:NPM1 (85%) (6p25.3) (30%) 
t(2;v) (15%) Recurrent translocations involving TP63 (3q28) 8% 
Gains: 7, 17p, 17q Gains: 1q, 6p, 8q, 12q 
Deletions: 4, 11q, 13q Deletions: 6q, 4q, 13q 
ALK+ ALCLALK- ALCL
Recurrent translocations involving ALK Recurrent translocations involving DUSP22:IRF4 
t(2;5)(p23;25) ALK:NPM1 (85%) (6p25.3) (30%) 
t(2;v) (15%) Recurrent translocations involving TP63 (3q28) 8% 
Gains: 7, 17p, 17q Gains: 1q, 6p, 8q, 12q 
Deletions: 4, 11q, 13q Deletions: 6q, 4q, 13q 

v, variant partner30,38,40

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