Significant nonhematologic toxicities
| Adverse event . | Cohort . | ||||||
|---|---|---|---|---|---|---|---|
| A1 . | B1 . | A2 . | B2 . | A3 . | B3 . | Total . | |
| Febrile neutropenia | 5 | 4 | 3 | 5 | 5 | 5 | 27 |
| Infection and neutropenia | 3 | 1 | 2 | 5 | 2 | 2 | 15 |
| LFT abnormality | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
| Rash | 0 | 0 | 1 | 0 | 1 | 0 | 2 |
| GI toxicity | 0 | 1 | 0 | 0 | 3 | 5 | 9 |
| Mucositis | 1 | 3 | 2 | 6 | |||
| Enteritis | 1 | 1 | |||||
| Colitis | 4 | 4 | |||||
| Adverse event . | Cohort . | ||||||
|---|---|---|---|---|---|---|---|
| A1 . | B1 . | A2 . | B2 . | A3 . | B3 . | Total . | |
| Febrile neutropenia | 5 | 4 | 3 | 5 | 5 | 5 | 27 |
| Infection and neutropenia | 3 | 1 | 2 | 5 | 2 | 2 | 15 |
| LFT abnormality | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
| Rash | 0 | 0 | 1 | 0 | 1 | 0 | 2 |
| GI toxicity | 0 | 1 | 0 | 0 | 3 | 5 | 9 |
| Mucositis | 1 | 3 | 2 | 6 | |||
| Enteritis | 1 | 1 | |||||
| Colitis | 4 | 4 | |||||
The most common grade 3 nonhematologic toxicities are shown (there were no grade 4 nonhematologic toxicities). The number of subjects with toxicity is shown for each cohort. In cohort B3, two patients experienced both mucositis and colitis—one had a history of Crohn disease. LFT abnormality indicates liver function test abnormality (serum transaminitis or hyperbilirubinemia).