Multiple Notch1 mutations are detected in preleukemic Tal1/Lmo2 thymic progenitors
| Mouse no. . | Thymic subset . | Nucleotide change . | Amino acid change . |
|---|---|---|---|
| 9401 | DN3 | 7161 C→G, ins G | 2387 T→R |
| 7873 del TA | 2626 Y→F | ||
| 7542 del C | 2515 I→S | ||
| 7926 del A | 2643 K→N | ||
| 7888 del T | 2631 S→L | ||
| 9401 | DN4 | 7098 del T | 2367 T→H |
| 7272 ins AAGGAAG | 2425 G→R | ||
| 7313 del G | 2438 G→E | ||
| 7264 ins C | 2425 G→A | ||
| 7751 C→T | 2584 A→V | ||
| 7722 del T | 2576 W→G | ||
| 7788 ins G | 2597 Y→I | ||
| 7883 ins T | 2629 L→I | ||
| 9446 | DN3 | 7535 ins G | 2512 P→R |
| 7792 del A | 2599 R→E | ||
| 7844 del T | 2616 L→Y | ||
| 7806 del A | 2603 E→N | ||
| 9446 | DN4 | 7792 del A | 2600 R→E |
| 7752 ins G | 2586 G→W | ||
| 7831 T→C | 2611 F→L | ||
| 9448 | DN3 | 7852 del TC | 2618 S→H |
| 7775 del A | 2594 M→C | ||
| 7869 del T | 2626 Y→I | ||
| 7415 del TCCATGGTCCC | 2472 L→H | ||
| 9448 | DN4 | 7673 T→C | 2558 T→I |
| 7316 ins ACA | 2439 A→D, ins T |
| Mouse no. . | Thymic subset . | Nucleotide change . | Amino acid change . |
|---|---|---|---|
| 9401 | DN3 | 7161 C→G, ins G | 2387 T→R |
| 7873 del TA | 2626 Y→F | ||
| 7542 del C | 2515 I→S | ||
| 7926 del A | 2643 K→N | ||
| 7888 del T | 2631 S→L | ||
| 9401 | DN4 | 7098 del T | 2367 T→H |
| 7272 ins AAGGAAG | 2425 G→R | ||
| 7313 del G | 2438 G→E | ||
| 7264 ins C | 2425 G→A | ||
| 7751 C→T | 2584 A→V | ||
| 7722 del T | 2576 W→G | ||
| 7788 ins G | 2597 Y→I | ||
| 7883 ins T | 2629 L→I | ||
| 9446 | DN3 | 7535 ins G | 2512 P→R |
| 7792 del A | 2599 R→E | ||
| 7844 del T | 2616 L→Y | ||
| 7806 del A | 2603 E→N | ||
| 9446 | DN4 | 7792 del A | 2600 R→E |
| 7752 ins G | 2586 G→W | ||
| 7831 T→C | 2611 F→L | ||
| 9448 | DN3 | 7852 del TC | 2618 S→H |
| 7775 del A | 2594 M→C | ||
| 7869 del T | 2626 Y→I | ||
| 7415 del TCCATGGTCCC | 2472 L→H | ||
| 9448 | DN4 | 7673 T→C | 2558 T→I |
| 7316 ins ACA | 2439 A→D, ins T |