Gene mutations and clinical aspects
| Gene mutations . | Sex . | Mean age, y . | Median WBC count, x109/L (range) . | Median BM blasts, % (range) . | |
|---|---|---|---|---|---|
| No. of the patients . | |||||
| Male . | Female . | ||||
| FLT3 ITD or TKD (missing = 54) | |||||
| Mutated | 68 | 47 | 38.2 ± 19.5 | 23.5 (0.5-447.6) | 70.5 (22.5-94.0) |
| Unmutated | 563 | 453 | 38.4 ± 18.8 | 7 (0.3-390.0) | 65.0 (22.5-97.0) |
| P | .489 | .903 | < .001 | < .001 | |
| C-KIT (missing = 63) | |||||
| Mutated | 47 | 31 | 35.3 ± 19.2 | 13.6 (0.8-197.0) | 67.0 (37.6-90.0) |
| Unmutated | 577 | 467 | 38.7 ± 18.9 | 7.7 (0.3-453.0) | 65.0 (22.5-97.0) |
| P | .411 | .127 | .912 | .453 | |
| N-RAS (missing = 59) | |||||
| Mutated | 46 | 28 | 38.5 ± 19.0 | 17.5 (1.0-185.7) | 68.0 (37.0-97.0) |
| Unmutated | 583 | 469 | 38.9 ± 20.2 | 7.6 (0.3-453.0) | 65.0 (22.5-97.0) |
| P | .278 | .854 | .269 | .139 | |
| NPM1 (missing = 36) | |||||
| Mutated | 61 | 68 | 50.1 ± 16.1 | 29.3 (0.6-389.4) | 71.5 (23.0-97.0) |
| Unmutated | 576 | 444 | 37.1 ± 18.9 | 7.25 (0.3-453.0) | 65.0 (22.5-97.0) |
| P | .049 | < .001 | < .001 | < .001 | |
| CEBPA (missing = 54) | |||||
| Mutated | 84 | 54 | 43.2 ± 17.0 | 13.95 (1.0-453.0) | 68.0 (25.5-91.0) |
| Unmutated | 546 | 447 | 37.7 ± 19.2 | 7.1 (0.3-447.6) | 65.0 (22.5-97.0) |
| P | .201 | .001 | < .001 | .291 | |
| WT1 (missing = 128) | |||||
| Mutated | 24 | 23 | 36.3 ± 18.9 | 10.2 (0.9-138.9) | 69.0 (23.5-90.0) |
| Unmutated | 565 | 445 | 38.6 ± 19.0 | 8.1 (0.3-453.0) | 65.5 (22.5-97.0) |
| P | .550 | .416 | .528 | .325 | |
| ASXL1 (missing = 168) | |||||
| Mutated | 20 | 15 | 42.9 ± 21.5 | 11.8 (0.8-142.0) | 62.0 (22.5-87.0) |
| Unmutated | 550 | 432 | 38.4 ± 18.9 | 8.0 (0.3-453.0) | 66.3 (22.5-97.0) |
| P | > .999 | .162 | .488 | .096 | |
| DNMT3A (missing = 44) | |||||
| Mutated | 45 | 30 | 53.5 ± 15.5 | 37.9 (1.1-447.6) | 78.0 (32.0-97.0) |
| Unmutated | 592 | 474 | 37.5 ± 18.9 | 7.3 (0.3-453.0) | 65.0 (22.5-97.0) |
| P | .548 | < .001 | < .001 | < .001 | |
| MLL (missing = 20) | |||||
| Abnormal | 48 | 36 | 38.9 ± 18.6 | 10.95 (0.6-447.6) | 74.0 (28.5-96.0) |
| Normal | 601 | 480 | 38.5 ± 19.1 | 7.8 (0.3-453.0) | 65.0 (28.5-97.0) |
| P | .820 | .844 | .003 | < .001 | |
| IDH1 (missing = 78) | |||||
| Mutated | 34 | 30 | 47.5 ± 18.1 | 10.1 (0.6-255.0) | 68.0 (35.0-97.0) |
| Unmutated | 585 | 458 | 37.7 ± 19.0 | 7.8 (0.3-453.0) | 65.0 (22.5-96.0) |
| P | .698 | < .001 | .828 | .872 | |
| IDH2 (missing = 128) | |||||
| Mutated | 30 | 31 | 51.8 ± 15.9 | 12.1 (1.1-447.6) | 68.0 (30.5-94.0) |
| Unmutated | 558 | 438 | 37.8 ± 18.9 | 8.0 (0.3-453.0) | 65.5 (22.5-97.0) |
| P | .353 | < .001 | .014 | .566 | |
| TET2 (missing = 175) | |||||
| Mutated | 40 | 46 | 45.9 ± 18.5 | 12.4 (0.9-453.0) | 67.0 (23.5-95.0) |
| Unmutated | 523 | 401 | 38.0 ± 18.8 | 7.9 (0.3-447.6) | 65.5 (22.5-97.0) |
| P | .144 | < .001 | .224 | .910 | |
| Gene mutations . | Sex . | Mean age, y . | Median WBC count, x109/L (range) . | Median BM blasts, % (range) . | |
|---|---|---|---|---|---|
| No. of the patients . | |||||
| Male . | Female . | ||||
| FLT3 ITD or TKD (missing = 54) | |||||
| Mutated | 68 | 47 | 38.2 ± 19.5 | 23.5 (0.5-447.6) | 70.5 (22.5-94.0) |
| Unmutated | 563 | 453 | 38.4 ± 18.8 | 7 (0.3-390.0) | 65.0 (22.5-97.0) |
| P | .489 | .903 | < .001 | < .001 | |
| C-KIT (missing = 63) | |||||
| Mutated | 47 | 31 | 35.3 ± 19.2 | 13.6 (0.8-197.0) | 67.0 (37.6-90.0) |
| Unmutated | 577 | 467 | 38.7 ± 18.9 | 7.7 (0.3-453.0) | 65.0 (22.5-97.0) |
| P | .411 | .127 | .912 | .453 | |
| N-RAS (missing = 59) | |||||
| Mutated | 46 | 28 | 38.5 ± 19.0 | 17.5 (1.0-185.7) | 68.0 (37.0-97.0) |
| Unmutated | 583 | 469 | 38.9 ± 20.2 | 7.6 (0.3-453.0) | 65.0 (22.5-97.0) |
| P | .278 | .854 | .269 | .139 | |
| NPM1 (missing = 36) | |||||
| Mutated | 61 | 68 | 50.1 ± 16.1 | 29.3 (0.6-389.4) | 71.5 (23.0-97.0) |
| Unmutated | 576 | 444 | 37.1 ± 18.9 | 7.25 (0.3-453.0) | 65.0 (22.5-97.0) |
| P | .049 | < .001 | < .001 | < .001 | |
| CEBPA (missing = 54) | |||||
| Mutated | 84 | 54 | 43.2 ± 17.0 | 13.95 (1.0-453.0) | 68.0 (25.5-91.0) |
| Unmutated | 546 | 447 | 37.7 ± 19.2 | 7.1 (0.3-447.6) | 65.0 (22.5-97.0) |
| P | .201 | .001 | < .001 | .291 | |
| WT1 (missing = 128) | |||||
| Mutated | 24 | 23 | 36.3 ± 18.9 | 10.2 (0.9-138.9) | 69.0 (23.5-90.0) |
| Unmutated | 565 | 445 | 38.6 ± 19.0 | 8.1 (0.3-453.0) | 65.5 (22.5-97.0) |
| P | .550 | .416 | .528 | .325 | |
| ASXL1 (missing = 168) | |||||
| Mutated | 20 | 15 | 42.9 ± 21.5 | 11.8 (0.8-142.0) | 62.0 (22.5-87.0) |
| Unmutated | 550 | 432 | 38.4 ± 18.9 | 8.0 (0.3-453.0) | 66.3 (22.5-97.0) |
| P | > .999 | .162 | .488 | .096 | |
| DNMT3A (missing = 44) | |||||
| Mutated | 45 | 30 | 53.5 ± 15.5 | 37.9 (1.1-447.6) | 78.0 (32.0-97.0) |
| Unmutated | 592 | 474 | 37.5 ± 18.9 | 7.3 (0.3-453.0) | 65.0 (22.5-97.0) |
| P | .548 | < .001 | < .001 | < .001 | |
| MLL (missing = 20) | |||||
| Abnormal | 48 | 36 | 38.9 ± 18.6 | 10.95 (0.6-447.6) | 74.0 (28.5-96.0) |
| Normal | 601 | 480 | 38.5 ± 19.1 | 7.8 (0.3-453.0) | 65.0 (28.5-97.0) |
| P | .820 | .844 | .003 | < .001 | |
| IDH1 (missing = 78) | |||||
| Mutated | 34 | 30 | 47.5 ± 18.1 | 10.1 (0.6-255.0) | 68.0 (35.0-97.0) |
| Unmutated | 585 | 458 | 37.7 ± 19.0 | 7.8 (0.3-453.0) | 65.0 (22.5-96.0) |
| P | .698 | < .001 | .828 | .872 | |
| IDH2 (missing = 128) | |||||
| Mutated | 30 | 31 | 51.8 ± 15.9 | 12.1 (1.1-447.6) | 68.0 (30.5-94.0) |
| Unmutated | 558 | 438 | 37.8 ± 18.9 | 8.0 (0.3-453.0) | 65.5 (22.5-97.0) |
| P | .353 | < .001 | .014 | .566 | |
| TET2 (missing = 175) | |||||
| Mutated | 40 | 46 | 45.9 ± 18.5 | 12.4 (0.9-453.0) | 67.0 (23.5-95.0) |
| Unmutated | 523 | 401 | 38.0 ± 18.8 | 7.9 (0.3-447.6) | 65.5 (22.5-97.0) |
| P | .144 | < .001 | .224 | .910 | |
MLL variants include MLL fusion genes and PTD mutations. Missing refers to the samples failed to detect the mutation results in assays.
WBC indicates white blood cell; BM, bone marrow; and no., number.