Table 3 Multivariate analysis for... | American Society of Hematology

Table 3

Multivariate analysis for clinical and molecular variables of CR, OS, and EFS

Variables	CR		OS		EFS
Variables	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)
Age	< .001	0.976 (0.965-0.987)	< .001	1.018 (1.011-1.027)	< .001	1.013 (1.006-1.020)
WBC count	.020	0.996 (0.992-0.999)	.022	1.002 (1.000-1.004)	.044	1.002 (1.000-1.004)
BM blasts	NS		NS		NS
FLT3 ITD or TKD	NS		NS		NS
C-KIT	NS		NS		NS
N-RAS	NS		NS		NS
NPM1 m+/DNMT3A m-	.001	2.533 (1.430-4.488)	.014	0.626 (0.431-0.910)	.012	0.638 (0.450-0.906)
Bi-allelic CEBPA	.005	2.450 (1.319-4.553)	< .001	0.396 (0.214-0.650)	.001	0.488 (0.319-0.746)
WT1	NS		NS		NS
ASXL1	NS		NS		NS
DNMT3A	.036	0.486 (0.248-0.953)	.005	1.753 (1.189-2.583)	.010	1.638 (1.123-2.388)
MLL variants	NS		.002	1.803 (1.240-2.623)	.004	1.642 (1.167-2.311)
IDH1	NS		NS		NS
IDH2	NS		NS		NS
TET2	NS		NS		NS

Variables	CR		OS		EFS
Variables	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)
Age	< .001	0.976 (0.965-0.987)	< .001	1.018 (1.011-1.027)	< .001	1.013 (1.006-1.020)
WBC count	.020	0.996 (0.992-0.999)	.022	1.002 (1.000-1.004)	.044	1.002 (1.000-1.004)
BM blasts	NS		NS		NS
FLT3 ITD or TKD	NS		NS		NS
C-KIT	NS		NS		NS
N-RAS	NS		NS		NS
NPM1 m+/DNMT3A m-	.001	2.533 (1.430-4.488)	.014	0.626 (0.431-0.910)	.012	0.638 (0.450-0.906)
Bi-allelic CEBPA	.005	2.450 (1.319-4.553)	< .001	0.396 (0.214-0.650)	.001	0.488 (0.319-0.746)
WT1	NS		NS		NS
ASXL1	NS		NS		NS
DNMT3A	.036	0.486 (0.248-0.953)	.005	1.753 (1.189-2.583)	.010	1.638 (1.123-2.388)
MLL variants	NS		.002	1.803 (1.240-2.623)	.004	1.642 (1.167-2.311)
IDH1	NS		NS		NS
IDH2	NS		NS		NS
TET2	NS		NS		NS

MLL variants include MLL fusion genes and PTD mutations.