Pathways coregulated with PIM kinases among B-cell NHL types
| . | Pathway . | PIM1 . | PIM2 . | PIM3 . |
|---|---|---|---|---|
| Positive | IL2RB pathway | 0.053 | ||
| JAK/STAT pathway | 0.056 | |||
| JAK/STAT receptors | 0.076 | |||
| IL2 pathway | 0.076 | |||
| p38 MAPK pathway | 0.129 | |||
| BM plasma cell | 0.126 | |||
| NF-κB total pathway | 0.118 | |||
| CD40 signalling during GC dev | 0.123 | |||
| B cells_IgM_IgD_CD27+ | 0.105 | 0.159 | ||
| IL6 pathway | 0.160 | |||
| IL3 pathway | 0.177 | |||
| NF-κB pathway canonic | 0.183 | |||
| T-cell cytokine signalling | 0.175 | |||
| NF-κB target genes | 0.226 | |||
| Dendritic cell pathway | 0.224 | |||
| MAPK pathway | 0.212 | |||
| Plasmacytoid dendritic cell | 0.204 | |||
| NKT pathway | 0.230 | |||
| RELA pathway | 0.228 | |||
| TNFR2 pathway | 0.237 | |||
| Blood monocyte | 0.196 | |||
| Negative | BLIMP-1 targets | 0.198 | ||
| G2 pathway | 0.170 | |||
| Apoptosis_CCG | 0.134 | |||
| Cell cycle pathway | 0.150 | |||
| c-Myc targets | 0.136 | |||
| CK1 pathway | 0.160 | |||
| Genes up-regulated by Myc | 0.142 | |||
| Creb pathway | 0.169 |
| . | Pathway . | PIM1 . | PIM2 . | PIM3 . |
|---|---|---|---|---|
| Positive | IL2RB pathway | 0.053 | ||
| JAK/STAT pathway | 0.056 | |||
| JAK/STAT receptors | 0.076 | |||
| IL2 pathway | 0.076 | |||
| p38 MAPK pathway | 0.129 | |||
| BM plasma cell | 0.126 | |||
| NF-κB total pathway | 0.118 | |||
| CD40 signalling during GC dev | 0.123 | |||
| B cells_IgM_IgD_CD27+ | 0.105 | 0.159 | ||
| IL6 pathway | 0.160 | |||
| IL3 pathway | 0.177 | |||
| NF-κB pathway canonic | 0.183 | |||
| T-cell cytokine signalling | 0.175 | |||
| NF-κB target genes | 0.226 | |||
| Dendritic cell pathway | 0.224 | |||
| MAPK pathway | 0.212 | |||
| Plasmacytoid dendritic cell | 0.204 | |||
| NKT pathway | 0.230 | |||
| RELA pathway | 0.228 | |||
| TNFR2 pathway | 0.237 | |||
| Blood monocyte | 0.196 | |||
| Negative | BLIMP-1 targets | 0.198 | ||
| G2 pathway | 0.170 | |||
| Apoptosis_CCG | 0.134 | |||
| Cell cycle pathway | 0.150 | |||
| c-Myc targets | 0.136 | |||
| CK1 pathway | 0.160 | |||
| Genes up-regulated by Myc | 0.142 | |||
| Creb pathway | 0.169 |
Values are of the significance of false discovery rate. We conducted gene set enrichment analysis in the complete series of patients (including DLBCL, FL, MALT, MCL, CLL, and NMZL) and controls (lymph nodes and reactive tonsils). We used the Pearson correlation coefficient to identify pathways coregulated with the expression of either PIM1, PIM2, or PIM3 genes. PIM2 expression was significantly associated with a larger series of significant gene sets.