Impacts of clinicopathologic parameters on survival in 76 APL patients on oral As2O3 maintenance regimens
| Clinicopathologic parameters . | 3-y survivals, % . | |||||
|---|---|---|---|---|---|---|
| LFS . | P (log-rank) . | EFS . | P (log-rank) . | OS . | P (log-rank) . | |
| Sex | ||||||
| Male | 71 | 73 | 92 | |||
| Female | 100 | .014 | 92 | NS (.15) | 90 | NS (.85) |
| Age, y | ||||||
| ≤ 40 | 96 | 96 | 100 | |||
| > 40 | 83 | NS (.41) | 76 | NS (.10) | 89 | .03 |
| Presentation WBC count | ||||||
| ≤ 10 × 109/L | 90 | 85 | 100 | |||
| > 10 × 109/L | 77 | NS (.38) | 77 | NS (.84) | 92 | NS (.18) |
| Presentation platelet count | ||||||
| < 40 × 109/L | 88 | 86 | 96 | |||
| ≥ 40 × 109/L | 88 | NS (.61) | 77 | NS (.12) | 85 | NS (.09) |
| APL differentiation syndrome | ||||||
| Present | 78 | 69 | 92 | |||
| Absent | 91 | NS (.31) | 88 | NS (.26) | 94 | NS (.95) |
| Peak WBC count | ||||||
| ≤ 10 × 109/L | 94 | 51 | 90 | |||
| > 10 × 109/L | 80 | NS (.34) | 77 | NS (.70) | 97 | NS (.45) |
| Maintenance regimens | ||||||
| A | 85 | 80 | 90 | |||
| AA | 90 | 90 | 100 | |||
| AAA | 92 | NS (.99) | 87 | NS (.87) | 92 | NS (.19) |
| Second cancers | ||||||
| Present | 87 | 68 | 71 | |||
| Absent | 90 | NS (.84) | 87 | NS (.08) | 100 | < .001 |
| Clinicopathologic parameters . | 3-y survivals, % . | |||||
|---|---|---|---|---|---|---|
| LFS . | P (log-rank) . | EFS . | P (log-rank) . | OS . | P (log-rank) . | |
| Sex | ||||||
| Male | 71 | 73 | 92 | |||
| Female | 100 | .014 | 92 | NS (.15) | 90 | NS (.85) |
| Age, y | ||||||
| ≤ 40 | 96 | 96 | 100 | |||
| > 40 | 83 | NS (.41) | 76 | NS (.10) | 89 | .03 |
| Presentation WBC count | ||||||
| ≤ 10 × 109/L | 90 | 85 | 100 | |||
| > 10 × 109/L | 77 | NS (.38) | 77 | NS (.84) | 92 | NS (.18) |
| Presentation platelet count | ||||||
| < 40 × 109/L | 88 | 86 | 96 | |||
| ≥ 40 × 109/L | 88 | NS (.61) | 77 | NS (.12) | 85 | NS (.09) |
| APL differentiation syndrome | ||||||
| Present | 78 | 69 | 92 | |||
| Absent | 91 | NS (.31) | 88 | NS (.26) | 94 | NS (.95) |
| Peak WBC count | ||||||
| ≤ 10 × 109/L | 94 | 51 | 90 | |||
| > 10 × 109/L | 80 | NS (.34) | 77 | NS (.70) | 97 | NS (.45) |
| Maintenance regimens | ||||||
| A | 85 | 80 | 90 | |||
| AA | 90 | 90 | 100 | |||
| AAA | 92 | NS (.99) | 87 | NS (.87) | 92 | NS (.19) |
| Second cancers | ||||||
| Present | 87 | 68 | 71 | |||
| Absent | 90 | NS (.84) | 87 | NS (.08) | 100 | < .001 |
NS indicates not significant.