Copy number alterations in leukemic cells of twins
| Chromosome . | CNA . | Genes . | Twin . | ||
|---|---|---|---|---|---|
| 1A . | 1B . | 2A . | |||
| Associated with the translocation | |||||
| 9 | amp 9q(34.12–34.3) | ABL1 and several | x | ||
| 9 | del 9q(34.12) | ABL1 | x | x | |
| 22 | amp22q(11.1–11.23) | BCR and several | x | ||
| 22 | del 22q(11.23) | BCR | x | x | |
| “Neutral” (IgH/TcR somatic rearrangements) | |||||
| 7 | del 7p(12.2) | TCRG | x | x | |
| 14 | del 14q(32–33) | IgH* | x | x | |
| 14 | del 14q(32–33) | TCRD | x | ||
| 22 | del 22q(11.22) | IgL | x | ||
| “Driver” aberrations | |||||
| 5 | del 5q(33.3) | EBF1 | x | ||
| 9 | del 9p(12–23) | Several, including CDKN2A, PAX5 | x | ||
| 9 | gp 21.3 | CDKN2A biallelic deletion | x | ||
| 10 | del 10q(24.1) | PIK3AP1 | x | ||
| 14 | del 14q(11.2) | IKZF1 | x | x | |
| 21 | del 21q(22.13) | DSCR5 | x | ||
| Trisomy 4, 6, 9, 14, 17, X | x | ||||
| Tetrasomy 21 | x | ||||
| Chromosome . | CNA . | Genes . | Twin . | ||
|---|---|---|---|---|---|
| 1A . | 1B . | 2A . | |||
| Associated with the translocation | |||||
| 9 | amp 9q(34.12–34.3) | ABL1 and several | x | ||
| 9 | del 9q(34.12) | ABL1 | x | x | |
| 22 | amp22q(11.1–11.23) | BCR and several | x | ||
| 22 | del 22q(11.23) | BCR | x | x | |
| “Neutral” (IgH/TcR somatic rearrangements) | |||||
| 7 | del 7p(12.2) | TCRG | x | x | |
| 14 | del 14q(32–33) | IgH* | x | x | |
| 14 | del 14q(32–33) | TCRD | x | ||
| 22 | del 22q(11.22) | IgL | x | ||
| “Driver” aberrations | |||||
| 5 | del 5q(33.3) | EBF1 | x | ||
| 9 | del 9p(12–23) | Several, including CDKN2A, PAX5 | x | ||
| 9 | gp 21.3 | CDKN2A biallelic deletion | x | ||
| 10 | del 10q(24.1) | PIK3AP1 | x | ||
| 14 | del 14q(11.2) | IKZF1 | x | x | |
| 21 | del 21q(22.13) | DSCR5 | x | ||
| Trisomy 4, 6, 9, 14, 17, X | x | ||||
| Tetrasomy 21 | x | ||||
Different sequences in twin pairs 1A,B.