Baseline characteristics by responders (CR, CRi, and PR) and nonresponders
| Characteristic . | Responders (n = 5) . | Nonresponders (n = 32) . |
|---|---|---|
| Median age in years (range) | 68 (60-79) | 74 (60-94) |
| Sex, female/male | 2/3 | 19/13 |
| Race (white/black or nonwhite) | 5/0 | 28/4 |
| Prior MDS diagnosis, % | 3 (60%) | 16 (50%) |
| Median baseline laboratory measurements (range) | ||
| WBC, ×103/mL | 2.1 (0.6-11.1) | 2.7 (0.7-658.0) |
| Platelets, ×103/mL | 73 (28-166) | 51 (6-4000) |
| Peripheral blasts, % | 0 (0-58) | 6 (0-72) |
| Marrow blasts, % | 45 (27-90) | 36 (17-70) |
| Zubrod performance status, n (%) | ||
| 0 | 2 (40%) | 5 (16%) |
| 1 | 3 (60%) | 18 (56%) |
| 2 | 0 | 7 (22%) |
| 3 | 0 | 2 (6%) |
| Cytogenetics | ||
| Number of abnormalities, median n (range) | 8 (1-20) | 8 (0-31) |
| Normal cells within patient, median % (range) | 30 (25-60) | 5 (0-100) |
| del(5q) cells within patient, median % (range)* | 70 (30-75) | 95 (0-100) |
| Patients with 100% of tumor cells w/ del(5q), %* | 3 (60%) | 21 (84%) |
| −5 abnormality, n (%) | 1 (20%) | 2 (8%) |
| −7 abnormality, n (%) | 2 (40%) | 6 (24%) |
| del(7q) abnormality, n (%) | 1 (20%) | 2 (8%) |
| Characteristic . | Responders (n = 5) . | Nonresponders (n = 32) . |
|---|---|---|
| Median age in years (range) | 68 (60-79) | 74 (60-94) |
| Sex, female/male | 2/3 | 19/13 |
| Race (white/black or nonwhite) | 5/0 | 28/4 |
| Prior MDS diagnosis, % | 3 (60%) | 16 (50%) |
| Median baseline laboratory measurements (range) | ||
| WBC, ×103/mL | 2.1 (0.6-11.1) | 2.7 (0.7-658.0) |
| Platelets, ×103/mL | 73 (28-166) | 51 (6-4000) |
| Peripheral blasts, % | 0 (0-58) | 6 (0-72) |
| Marrow blasts, % | 45 (27-90) | 36 (17-70) |
| Zubrod performance status, n (%) | ||
| 0 | 2 (40%) | 5 (16%) |
| 1 | 3 (60%) | 18 (56%) |
| 2 | 0 | 7 (22%) |
| 3 | 0 | 2 (6%) |
| Cytogenetics | ||
| Number of abnormalities, median n (range) | 8 (1-20) | 8 (0-31) |
| Normal cells within patient, median % (range) | 30 (25-60) | 5 (0-100) |
| del(5q) cells within patient, median % (range)* | 70 (30-75) | 95 (0-100) |
| Patients with 100% of tumor cells w/ del(5q), %* | 3 (60%) | 21 (84%) |
| −5 abnormality, n (%) | 1 (20%) | 2 (8%) |
| −7 abnormality, n (%) | 2 (40%) | 6 (24%) |
| del(7q) abnormality, n (%) | 1 (20%) | 2 (8%) |
WBC indicates white blood cell count; and MC, metaphase cytogenetics.
Excluding cells with monosomy 5 (−5).