Table 7 Summary of risk factors for... | American Society of Hematology

Table 7

Summary of risk factors for AGVHD, transplantation-related mortality, and overall mortality for SD and URD cohorts

Variable*	AGVHD grades B-D		AGVHD grades C-D		Transplantation-related mortality		Overall mortality
Variable*	SD	URD	SD	URD	SD	URD	SD	URD
MA + TBI + PBSC	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
MA + TBI + BM	—	↓	—	↓	—	—	↓	—
MA + nonTBI + PBSC	—	—	—	—	—	—	↓	—
MA + nonTBI + BM	↓	↓	↓	↓	—	—	—	—
RIC + PBSC	↓	↓	—	—	—	↓	—	—
RIC + BM	—	↓	—	↓	—	—	—	—
Tacrolimus-based GVHD prophylaxis	↓	↓	↓	—	↓	—	↓	—
Older recipient age	—	—	—	—	↑	↑	↑	↑
Older donor age	—	—	—	—	—	↑	—	↑
Higher KPS	—	—	—	—	↓	↓	↓	↓
Disease type other than ALL	—	↑	—	↑	↓	—	↓	↓
Disease status other than early	—	—	↑	—	↑	↑	↑	↑
Female donor for male recipient	—		↑	—	↑	↑	↑	—
CMV other than NN	—	—	—	—	—	↑	—	↑
ABO mismatch	—	—	—	—	—	↑	—	↑
HLA mismatch	NA	↑	—	↑	NA	↑	NA	↑

Variable*	AGVHD grades B-D		AGVHD grades C-D		Transplantation-related mortality		Overall mortality
Variable*	SD	URD	SD	URD	SD	URD	SD	URD
MA + TBI + PBSC	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
MA + TBI + BM	—	↓	—	↓	—	—	↓	—
MA + nonTBI + PBSC	—	—	—	—	—	—	↓	—
MA + nonTBI + BM	↓	↓	↓	↓	—	—	—	—
RIC + PBSC	↓	↓	—	—	—	↓	—	—
RIC + BM	—	↓	—	↓	—	—	—	—
Tacrolimus-based GVHD prophylaxis	↓	↓	↓	—	↓	—	↓	—
Older recipient age	—	—	—	—	↑	↑	↑	↑
Older donor age	—	—	—	—	—	↑	—	↑
Higher KPS	—	—	—	—	↓	↓	↓	↓
Disease type other than ALL	—	↑	—	↑	↓	—	↓	↓
Disease status other than early	—	—	↑	—	↑	↑	↑	↑
Female donor for male recipient	—		↑	—	↑	↑	↑	—
CMV other than NN	—	—	—	—	—	↑	—	↑
ABO mismatch	—	—	—	—	—	↑	—	↑
HLA mismatch	NA	↑	—	↑	NA	↑	NA	↑

NN indicates negative/negative serostatus; MA, myeloablative; —, no association; Ref, reference; NA, not applicable; ↑, increased risk/odd of association with outcome; and ↓, decreased risk/odd of association with outcome.

See individual tables of multivariate analyses for reference groups.

View Large

This Feature Is Available To Subscribers Only