Relative risk of chronic health conditions and adverse health status among HSCT survivors (BMTSS), as compared with sibling controls (CCSS)
| . | Grades 1-4 (95% CI) . | Grade 3 or 4 (95% CI) . | ≥ 2 conditions (95% CI) . | Poor general health (95% CI) . | Functional impairment (95% CI) . | Activity limitation (95% CI) . |
|---|---|---|---|---|---|---|
| Siblings (CCSS) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| BMTSS | 2.6 (2.4-2.9) | 8.1 (6.2-10.5) | 5.7 (4.9-6.7) | 3.2 (2.0-4.9) | 7.7 (5.1-11.5) | 6.3 (4.7–8.5) |
| P | < .01 | < .01 | < .01 | < .01 | < .01 | < .01 |
| Donor source, BMTSS* | ||||||
| Autologous | 2.5 (2.0-3.1) | 6.5 (3.7-11.6) | 4.7 (3.2-6.8) | 3.5 (1.5-7.9) | 6.9 (3.2-14.8) | 6.2 (3.6–10.9) |
| Allogeneic, related | 2.5 (2.3-2.9) | 8.0 (5.9-10.8) | 5.7 (4.8-8.9) | 3.2 (1.9-5.4) | 7.8 (4.9-12.6) | 5.9 (4.0–8.5) |
| Allogeneic, unrelated | 3.5 (2.7-4.6) | 13.5 (6.9-26.5) | 8.9 (5.9-13.4) | 2.0 (0.3-13.3) | 8.4 (2.8-24.9) | 10.1 (5.4–18.8) |
| P value (trend) | < .01 | < .01 | < .01 | < .01 | < .01 | < .01 |
| . | Grades 1-4 (95% CI) . | Grade 3 or 4 (95% CI) . | ≥ 2 conditions (95% CI) . | Poor general health (95% CI) . | Functional impairment (95% CI) . | Activity limitation (95% CI) . |
|---|---|---|---|---|---|---|
| Siblings (CCSS) | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| BMTSS | 2.6 (2.4-2.9) | 8.1 (6.2-10.5) | 5.7 (4.9-6.7) | 3.2 (2.0-4.9) | 7.7 (5.1-11.5) | 6.3 (4.7–8.5) |
| P | < .01 | < .01 | < .01 | < .01 | < .01 | < .01 |
| Donor source, BMTSS* | ||||||
| Autologous | 2.5 (2.0-3.1) | 6.5 (3.7-11.6) | 4.7 (3.2-6.8) | 3.5 (1.5-7.9) | 6.9 (3.2-14.8) | 6.2 (3.6–10.9) |
| Allogeneic, related | 2.5 (2.3-2.9) | 8.0 (5.9-10.8) | 5.7 (4.8-8.9) | 3.2 (1.9-5.4) | 7.8 (4.9-12.6) | 5.9 (4.0–8.5) |
| Allogeneic, unrelated | 3.5 (2.7-4.6) | 13.5 (6.9-26.5) | 8.9 (5.9-13.4) | 2.0 (0.3-13.3) | 8.4 (2.8-24.9) | 10.1 (5.4–18.8) |
| P value (trend) | < .01 | < .01 | < .01 | < .01 | < .01 | < .01 |
Model adjusted for age at the time of the study, sex, and race or ethnicity.
BMTSS indicates Bone Marrow Transplant Survivor Study; CCSS, Childhood Cancer Survivor Study; CI, confidence interval; and N/A, not applicable.
Referent group: sibling controls (CCSS).