Autophagy induction in CML cells after various drug treatments
| Drug . | Main drug target . | Cell type . | Drug affect . | Autophagy inhibitor . | Affect of drug and autophagy inhibitor . | Reference . |
|---|---|---|---|---|---|---|
| Crotoxin | Not known | Cell line (K562) | Apoptosis and autophagy induction | 3-MA NH4Cl | Increased cell death | 80 |
| SAHA | Histone deacetylases | Cell lines, primary CML MNC | Apoptosis and autophagy induction | 3-MA CQ | Increased cell death | 81,82 |
| Bafetinib | BCR-ABL | Cell line (K562) | Apoptosis and autophagy induction | CQ 3-MA | Increased cell death | 83 |
| Imatinib | BCR-ABL | Cell line (K562) | Apoptosis and autophagy induction | CQ | Increased cell death | 84 |
| Imatinib, dasatinib | BCR-ABL | Cell lines, primary CD34+ cells, including CD34+38− | Apoptosis and autophagy induction | CQ Bafilomycin A1 | Increased cell death | 49,50 |
| Imatinib | BCR-ABL | K562 | Apoptosis and autophagy induction | 3-MA | Increased cell death | 85 |
| OSI-027 | mTOR | Cell line (K562) | Apoptosis and autophagy induction | CQ | Increased cell death | 88 |
| Resveratrol | Not known AMPK? | Cell lines, primary CD34+ cells | Apoptosis and autophagy induction | Bafilomycin A1 | Decreased cell death | 89 |
| Drug . | Main drug target . | Cell type . | Drug affect . | Autophagy inhibitor . | Affect of drug and autophagy inhibitor . | Reference . |
|---|---|---|---|---|---|---|
| Crotoxin | Not known | Cell line (K562) | Apoptosis and autophagy induction | 3-MA NH4Cl | Increased cell death | 80 |
| SAHA | Histone deacetylases | Cell lines, primary CML MNC | Apoptosis and autophagy induction | 3-MA CQ | Increased cell death | 81,82 |
| Bafetinib | BCR-ABL | Cell line (K562) | Apoptosis and autophagy induction | CQ 3-MA | Increased cell death | 83 |
| Imatinib | BCR-ABL | Cell line (K562) | Apoptosis and autophagy induction | CQ | Increased cell death | 84 |
| Imatinib, dasatinib | BCR-ABL | Cell lines, primary CD34+ cells, including CD34+38− | Apoptosis and autophagy induction | CQ Bafilomycin A1 | Increased cell death | 49,50 |
| Imatinib | BCR-ABL | K562 | Apoptosis and autophagy induction | 3-MA | Increased cell death | 85 |
| OSI-027 | mTOR | Cell line (K562) | Apoptosis and autophagy induction | CQ | Increased cell death | 88 |
| Resveratrol | Not known AMPK? | Cell lines, primary CD34+ cells | Apoptosis and autophagy induction | Bafilomycin A1 | Decreased cell death | 89 |
AMPK indicates AMP-activated protein kinase; BCR-ABL, breakpoint cluster region-Abelson murine leukemia; CML, chronic myeloid leukemia; CQ, chloroquine; 3-MA, 3-methyladenine; MNC, mononuclear cell; mTOR, mammalian target of rapamycin; and SAHA, suberoylanilide hydroxamic acid.