Association between activating KIR genes and risk for B-ALL in white patients of Canadian non-French ancestry
| Gene . | Patients (n = 45), n (%) . | Control subjects (n = 245), n (%) . | OR (95% CI) . | z . | P . |
|---|---|---|---|---|---|
| 2DS1 | 5 (11.1) | 102 (41.6) | 0.18 (0.07-0.46) | −3.54 | 4.0 × 10−4 |
| 2DS2 | 10 (22.2) | 138 (56.3) | 0.22 (0.10-0.47) | −3.96 | 7.5 × 10−5 |
| 2DS3 | 3 (6.8) | 83 (33.9) | 0.14 (0.04-0.46) | −3.22 | .001 |
| 2DS4* | 21 (46.7) | 139 (56.7) | 0.67 (0.35-1.26) | −1.24 | .21 |
| 2DS5 | 7 (15.6) | 104 (42.4) | 0.25 (0.11-0.58) | −3.22 | .001 |
| 3DS1 | 9 (20.0) | 101 (41.2) | 0.36 (0.16-0.77) | −2.61 | .009 |
| Gene . | Patients (n = 45), n (%) . | Control subjects (n = 245), n (%) . | OR (95% CI) . | z . | P . |
|---|---|---|---|---|---|
| 2DS1 | 5 (11.1) | 102 (41.6) | 0.18 (0.07-0.46) | −3.54 | 4.0 × 10−4 |
| 2DS2 | 10 (22.2) | 138 (56.3) | 0.22 (0.10-0.47) | −3.96 | 7.5 × 10−5 |
| 2DS3 | 3 (6.8) | 83 (33.9) | 0.14 (0.04-0.46) | −3.22 | .001 |
| 2DS4* | 21 (46.7) | 139 (56.7) | 0.67 (0.35-1.26) | −1.24 | .21 |
| 2DS5 | 7 (15.6) | 104 (42.4) | 0.25 (0.11-0.58) | −3.22 | .001 |
| 3DS1 | 9 (20.0) | 101 (41.2) | 0.36 (0.16-0.77) | −2.61 | .009 |
The prefix KIR is not shown with the gene names.
OR indicates odds ratio; and CI, confidence interval.
KIR2DS4 was considered absent when the PCR amplified only the 22-bp deleted amplicon. It was considered present when the nonmutant amplicon was observed on the gel with or without the mutant band.