Histologic and flow cytometry features of the 2 patients affected with non-HCL mature B-cell lymphoproliferative disorders carrying the BRAF V600E mutation
| . | Case 1 . | Case 2 . |
|---|---|---|
| BM histology | ||
| Pattern | Interstitial | Interstitial, sinusoidal |
| Morphology | Lymphocyte/centrocyte | Prolymphocyte-like |
| CD20 | + | + |
| CD5 | − | − |
| CD23 | − | − |
| CD10 | − | − |
| DBA44 | − | − |
| CD25 | − | − |
| bcl1 | + | − |
| ANXA1 | − | − |
| Flow cytometry immuno-phenotyping | ||
| sIg | κ++ | κ+ |
| CD20 | ++ | ++ |
| CD5 | − | − |
| CD23 | − | − |
| FMC7 | + | + |
| CD10 | − | − |
| CD38 | − | − |
| DBA44 | − | − |
| CD25 | − | − |
| CD11c | − | + |
| CD103 | − | +/− |
| . | Case 1 . | Case 2 . |
|---|---|---|
| BM histology | ||
| Pattern | Interstitial | Interstitial, sinusoidal |
| Morphology | Lymphocyte/centrocyte | Prolymphocyte-like |
| CD20 | + | + |
| CD5 | − | − |
| CD23 | − | − |
| CD10 | − | − |
| DBA44 | − | − |
| CD25 | − | − |
| bcl1 | + | − |
| ANXA1 | − | − |
| Flow cytometry immuno-phenotyping | ||
| sIg | κ++ | κ+ |
| CD20 | ++ | ++ |
| CD5 | − | − |
| CD23 | − | − |
| FMC7 | + | + |
| CD10 | − | − |
| CD38 | − | − |
| DBA44 | − | − |
| CD25 | − | − |
| CD11c | − | + |
| CD103 | − | +/− |
HCL indicates hairy cell leukemia.