Clinical and laboratory findings for the AL amyloidosis patients studied
| . | Dominant heart population (n = 55) . | No-dominant heart population (n = 44) . |
|---|---|---|
| Median age, y (range) | 57 (34-83) | 57 (38-77) |
| Men/women | 35/20 | 29/15 |
| Plasma cell infiltration, %, median (IQR)* | 11 (7-15) | 5.5 (4-11) |
| Serum monoclonal component of the λ isotype, n (%) | ||
| Present | 55 (100) | 40 (91) |
| Light chains only | 29 (53) | 17 (39) |
| Urine monoclonal component of the λ isotype, n (%) | ||
| Present | 52 (95) | 38 (86) |
| Light chains only | 46 (84) | 30 (68) |
| Organs involved, n (%) | ||
| 1 | 19 (35) | 20 (45) |
| 2 | 20 (36) | 16 (36) |
| 3 | 12 (22) | 7 (16) |
| 4 | 2 (4) | 1 (2) |
| 5 | 1 (2) | 0 (0) |
| Heart parameters* | ||
| Interventricular septum thickness, mm, mean (SD) | 16.5 (2.7) | 11.9 (2.5) |
| Ejection fraction, %, mean (SD) | 49.9 (14.7) | 59.1(8.1) |
| NT-proBNP, serum, ng/L, mean (IQR) | 5288.9 (3090.7-13 009.3) | 322.9 (57.6-1049.1) |
| . | Dominant heart population (n = 55) . | No-dominant heart population (n = 44) . |
|---|---|---|
| Median age, y (range) | 57 (34-83) | 57 (38-77) |
| Men/women | 35/20 | 29/15 |
| Plasma cell infiltration, %, median (IQR)* | 11 (7-15) | 5.5 (4-11) |
| Serum monoclonal component of the λ isotype, n (%) | ||
| Present | 55 (100) | 40 (91) |
| Light chains only | 29 (53) | 17 (39) |
| Urine monoclonal component of the λ isotype, n (%) | ||
| Present | 52 (95) | 38 (86) |
| Light chains only | 46 (84) | 30 (68) |
| Organs involved, n (%) | ||
| 1 | 19 (35) | 20 (45) |
| 2 | 20 (36) | 16 (36) |
| 3 | 12 (22) | 7 (16) |
| 4 | 2 (4) | 1 (2) |
| 5 | 1 (2) | 0 (0) |
| Heart parameters* | ||
| Interventricular septum thickness, mm, mean (SD) | 16.5 (2.7) | 11.9 (2.5) |
| Ejection fraction, %, mean (SD) | 49.9 (14.7) | 59.1(8.1) |
| NT-proBNP, serum, ng/L, mean (IQR) | 5288.9 (3090.7-13 009.3) | 322.9 (57.6-1049.1) |
AL indicates amyloid light; IQR, interquartile range; and NT-proBNP, N-terminal pro-B-type natriuretic peptide.
Parameters that were significantly different between the 2 populations: plasma cell infiltration, P = .007; interventricular septum thickness, P < 10−4; ejection fraction, P = .0009; NT-proBNP serum concentrations, P < 10−4