Screen failures for entry into rituximab trial*
| Admission . | Number . | Received rituximab off-trial . |
|---|---|---|
| Died within 24 h of admission | 7 | N/A |
| Secondary TTP (eg, pregnancy, HIV, pancreatitis) | 14 | 1 |
| Other TMAs† | 10 | |
| Declined trial entry | 2 | 1 |
| Failed to meet criteria | 13 | 12 |
| Admission . | Number . | Received rituximab off-trial . |
|---|---|---|
| Died within 24 h of admission | 7 | N/A |
| Secondary TTP (eg, pregnancy, HIV, pancreatitis) | 14 | 1 |
| Other TMAs† | 10 | |
| Declined trial entry | 2 | 1 |
| Failed to meet criteria | 13 | 12 |
TTP indicates thrombocytopenic purpura; TMA, thrombotic microangiopathy; and N/A, not applicable.
Patients failing to meet the entry criteria included those < 18 years, failure to enroll within 3 days as per protocol, and referral due to refractory disease. A total of 46 cases failed inclusion criteria.
Other TMAs included atypical hemolytic uremic syndrome, malignant hypertension, acute systemic sclerosis, carcinoma, bacterial endocarditis, and herpes simplex encephalitis.