An algorithm for transitioning patients from argatroban to warfarin
| Argatroban dose . | Management . |
|---|---|
| ≤ 2 μg/kg per minute | Stop argatroban when INR on combined argatroban and warfarin is > 4 |
| Repeat INR in 4-6 hours | |
| If INR is < 2, restart argatroban at 10% increased dose | |
| Repeat procedure until INR ≥ 2 is achieved | |
| > 2 μg/kg per minute | Reduce argatroban dose to 2 μg/kg per minute |
| Repeat INR in 4-6 hours | |
| Stop argatroban when INR on combined argatroban and warfarin is > 4 | |
| Repeat INR in 4-6 hours | |
| If INR is < 2, restart argatroban at 10% increased dose | |
| Repeat procedure until INR ≥ 2 is achieved |
| Argatroban dose . | Management . |
|---|---|
| ≤ 2 μg/kg per minute | Stop argatroban when INR on combined argatroban and warfarin is > 4 |
| Repeat INR in 4-6 hours | |
| If INR is < 2, restart argatroban at 10% increased dose | |
| Repeat procedure until INR ≥ 2 is achieved | |
| > 2 μg/kg per minute | Reduce argatroban dose to 2 μg/kg per minute |
| Repeat INR in 4-6 hours | |
| Stop argatroban when INR on combined argatroban and warfarin is > 4 | |
| Repeat INR in 4-6 hours | |
| If INR is < 2, restart argatroban at 10% increased dose | |
| Repeat procedure until INR ≥ 2 is achieved |