Table 1 Summary of thymic tolerance... | American Society of Hematology

Table 1

Summary of thymic tolerance phenotype for OT-I and OT-II cells in RIP-mOVA and RIP-OVA^{hi transgenic mice}

Phenotype	OT-I Deletion	OT-II Deletion	OVA expression
RIP-mOVA
Aire dependent	Yes	Yes	Partial
DC dependent*		No
RIP-OVA^hi
Aire dependent	No	Yes	No
DC dependent*		Yes

Phenotype	OT-I Deletion	OT-II Deletion	OVA expression
RIP-mOVA
Aire dependent	Yes	Yes	Partial
DC dependent*		No
RIP-OVA^hi
Aire dependent	No	Yes	No
DC dependent*		Yes

DC indicates dendritic cell; OVA, ovalbumin; and RIP-mOVA, rat insulin promoter membrane-bound form of ovalbumin.

For simplicity, we have indicated whether tolerance was DC dependent, but formally we have only proven that it is mediated by BM-derived cell.