Table 2 Drug interactions with at least... | American Society of Hematology

Table 2

Drug interactions with at least 50% change in the exposure to dabigatran or rivaroxaban

Mechanism	Dabigatran		Rivaroxaban
Mechanism	Interacting drug	Δ exposure, %	Interacting drug	Δ exposure, %
P-gp inhibition	Ketoconazole*	150	Ketoconazole*	160
	Quinidine	53
	Amiodarone	60
	Verapamil	≃ 50†
P-gp induction	Rifampicin	−67	Rifampicin	−50
	St John's wort	ND	St John's wort	ND
CYP3A4 inhibition			Ketoconazole*	160
			Clarithromycin	50
			Ritonavir	50
CYP3A4 induction			Rifampicin	−50
			St John's wort	ND

Mechanism	Dabigatran		Rivaroxaban
Mechanism	Interacting drug	Δ exposure, %	Interacting drug	Δ exposure, %
P-gp inhibition	Ketoconazole*	150	Ketoconazole*	160
	Quinidine	53
	Amiodarone	60
	Verapamil	≃ 50†
P-gp induction	Rifampicin	−67	Rifampicin	−50
	St John's wort	ND	St John's wort	ND
CYP3A4 inhibition			Ketoconazole*	160
			Clarithromycin	50
			Ritonavir	50
CYP3A4 induction			Rifampicin	−50
			St John's wort	ND

ND indicates not determined.

Contraindicated.

Variable depending on the formulation of verapamil.