Clinical correlations according to karyotype
| Parameter . | Learning cohort . | Validation cohort . | ||||
|---|---|---|---|---|---|---|
| Normal karyotype (51 cases) . | Abnormal karyotype (14 cases) . | P . | Normal karyotype (54 cases) . | Abnormal karyotype (30 cases) . | P . | |
| Mean age, y (range) | 64 (31-84) | 69 (50-87) | NS | 63 (41-90) | 63 (32-84) | NS |
| M/F | 31/20 | 8/6 | NS | 34/20 | 23/7 | NS |
| Matutes score, 3/4/5 | 3/25/23 | 4/3/7 | .030 | 4/24/25 | 7/6/12 | .035 |
| Binet stage, A/B/C | 47/3/1 | 10/3/1 | .089 | 45/9/0 | 20/7/3 | .040 |
| CD38 positive/negative | 21/29 | 8/6 | NS | 11/41 | 12/18 | .079 |
| ZAP-70 positive/negative | 15/6 | 5/4 | NS | 16/31 | 15/11 | .083 |
| IGVH unmutated/mutated | ND | ND | 11/38 | 10/17 | .191 | |
| Therapy, yes/no | 16/35 | 11/3 | .002 | 6/48 | 19/11 | < .0001 |
| Parameter . | Learning cohort . | Validation cohort . | ||||
|---|---|---|---|---|---|---|
| Normal karyotype (51 cases) . | Abnormal karyotype (14 cases) . | P . | Normal karyotype (54 cases) . | Abnormal karyotype (30 cases) . | P . | |
| Mean age, y (range) | 64 (31-84) | 69 (50-87) | NS | 63 (41-90) | 63 (32-84) | NS |
| M/F | 31/20 | 8/6 | NS | 34/20 | 23/7 | NS |
| Matutes score, 3/4/5 | 3/25/23 | 4/3/7 | .030 | 4/24/25 | 7/6/12 | .035 |
| Binet stage, A/B/C | 47/3/1 | 10/3/1 | .089 | 45/9/0 | 20/7/3 | .040 |
| CD38 positive/negative | 21/29 | 8/6 | NS | 11/41 | 12/18 | .079 |
| ZAP-70 positive/negative | 15/6 | 5/4 | NS | 16/31 | 15/11 | .083 |
| IGVH unmutated/mutated | ND | ND | 11/38 | 10/17 | .191 | |
| Therapy, yes/no | 16/35 | 11/3 | .002 | 6/48 | 19/11 | < .0001 |
M/F indicates male/female; NS, not significant; and ND, not done.