Multivariate analysis of OS in patients receiving transplantation from a related donor with a 1-antigen mismatch in the GVH direction
| Variable . | Total (n = 327) . | Standard-risk (n = 175) . | High-risk (n = 133) . | |||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| HLA mismatch in the GVH direction | ||||||
| HLA-DR mismatch | 1.00 | 1.00 | 1.00 | |||
| HLA-A mismatch | 1.07 (0.73-1.56) | .737 | 0.98 (0.54-1.81) | .966 | 1.11 (0.65-1.89) | .701 |
| HLA-B mismatch | 1.57 (1.13-2.18) | .007 | 1.86 (1.14-3.01) | .012 | 1.36 (0.86-2.17) | .193 |
| HLA mismatch in the HVG direction | ||||||
| 0-1 mismatches | 1.00 | 1.00 | 1.00 | |||
| 2-3 mismatches | 1.27 (0.91-1.76) | .154 | 1.67 (0.98-2.85) | .061 | 1.06 (0.69-1.61) | .799 |
| Age, y | ||||||
| ≤ 50 | 1.00 | 1.00 | ||||
| > 50 | 1.52 (1.14-2.03) | .004 | 1.87 (1.21-2.91) | .005 | ||
| Disease risk | ||||||
| Standard | 1.00 | |||||
| High | 2.06 (1.53-2.78) | < .001 | ||||
| Unknown | 1.00 (0.53-1.89) | .989 | ||||
| Variable . | Total (n = 327) . | Standard-risk (n = 175) . | High-risk (n = 133) . | |||
|---|---|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | |
| HLA mismatch in the GVH direction | ||||||
| HLA-DR mismatch | 1.00 | 1.00 | 1.00 | |||
| HLA-A mismatch | 1.07 (0.73-1.56) | .737 | 0.98 (0.54-1.81) | .966 | 1.11 (0.65-1.89) | .701 |
| HLA-B mismatch | 1.57 (1.13-2.18) | .007 | 1.86 (1.14-3.01) | .012 | 1.36 (0.86-2.17) | .193 |
| HLA mismatch in the HVG direction | ||||||
| 0-1 mismatches | 1.00 | 1.00 | 1.00 | |||
| 2-3 mismatches | 1.27 (0.91-1.76) | .154 | 1.67 (0.98-2.85) | .061 | 1.06 (0.69-1.61) | .799 |
| Age, y | ||||||
| ≤ 50 | 1.00 | 1.00 | ||||
| > 50 | 1.52 (1.14-2.03) | .004 | 1.87 (1.21-2.91) | .005 | ||
| Disease risk | ||||||
| Standard | 1.00 | |||||
| High | 2.06 (1.53-2.78) | < .001 | ||||
| Unknown | 1.00 (0.53-1.89) | .989 | ||||
Only variables that remained after backward selection in the multivariate analysis are shown.