Multivariate analysis of TRM and relapse in patients with standard-risk diseases receiving transplantations from a related donor with a 1-antigen mismatch in the GVH direction
| Variable . | TRM (n = 164) . | Relapse (n = 164) . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| HLA mismatch in the GVH direction | ||||
| HLA-DR mismatch | 1.00 | 1.00 | ||
| HLA-A mismatch | 1.22 (0.59-2.52) | .587 | 0.70 (0.29-1.67) | .418 |
| HLA-B mismatch | 2.00 (1.09-3.65) | .025 | 0.80 (0.34-1.87) | .605 |
| HLA mismatch in the HVG direction | ||||
| 0-1 mismatches | 1.00 | 1.00 | ||
| 2-3 mismatches | 2.21 (1.14-4.28) | .019 | 0.67 (0.23-1.98) | .467 |
| Age, y | ||||
| ≤ 50 | 1.00 | |||
| > 50 | 2.08 (1.18-3.65) | .011 | ||
| Duration from diagnosis to transplantation | ||||
| < 6 mo | 1.00 | |||
| ≥ 6 mo | 2.40 (1.19-4.82) | .014 | ||
| Unknown | 2.23 (0.77-6.48) | .140 | ||
| Variable . | TRM (n = 164) . | Relapse (n = 164) . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| HLA mismatch in the GVH direction | ||||
| HLA-DR mismatch | 1.00 | 1.00 | ||
| HLA-A mismatch | 1.22 (0.59-2.52) | .587 | 0.70 (0.29-1.67) | .418 |
| HLA-B mismatch | 2.00 (1.09-3.65) | .025 | 0.80 (0.34-1.87) | .605 |
| HLA mismatch in the HVG direction | ||||
| 0-1 mismatches | 1.00 | 1.00 | ||
| 2-3 mismatches | 2.21 (1.14-4.28) | .019 | 0.67 (0.23-1.98) | .467 |
| Age, y | ||||
| ≤ 50 | 1.00 | |||
| > 50 | 2.08 (1.18-3.65) | .011 | ||
| Duration from diagnosis to transplantation | ||||
| < 6 mo | 1.00 | |||
| ≥ 6 mo | 2.40 (1.19-4.82) | .014 | ||
| Unknown | 2.23 (0.77-6.48) | .140 | ||
Only variables that remained after backward selection in the multivariate analysis are shown.