Table 1

Clinical characteristics of subjects at baseline and at follow-up

Negative groupConstitutional thrombophilia groupaPLAb groupP
796 279 517  
Age, y 30 (5) [17-44] 29 (4) [18-44] 29 (4) [16-41] .21 
Age > 35 y 43 (5.4%) 12 (4.3%) 15 (2.9%) .086 
Body mass index, kg/m2 25.6 (4.5) [15.3-36.1] 25.9 (4.2) [13.5-34.1] 26.0 (4.6) [15.3-37.0] .16 
    > 30 78 (9.8%) 29 (10.4%) 60 (11.6%) .58 
    < 18.5 12 (1.5%) 3 (1.1%) 5 (1%) .66 
Ethnicity    .87 
    White 753 (94.6%) 264 (94.6%) 489 (94.6%)  
    European 647 (81.3%) 227 (81.4%) 420 (81.2%)  
    North African 106 (13.3%) 37 (13.2%) 69 (13.4%)  
    Black African 36 (4.5%) 12 (4.3%) 22 (4.2%)  
    Asian 7 (0.9%) 3 (1.1%) 6 (1.2%)  
Pregnancy loss subtype     
    Embryonic at < 10 WG 483 (60.7%) 93 (33.3%) 206 (39.8%) < .0001 
    Fetal at ≥ 10 WG 313 (39.3%) 186 (66.6%) 311 (60.2%)  
    Primary 549 (68.9%) 185 (66.3%) 342 (66.1%) .49 
    Secondary 247 (31.1%) 94 (33.7%) 175 (33.9%)  
Inflammatory disease 7 (0.9%) 4 (1.4%) 32 (6.2%) < .0001 
Current smokers 83 (10.4%) 30 (10.8%) 50 (9.7%) .89 
Hypertension 19 (2.4%) 8 (2.9%) 17 (3.3%) .62 
Positive history in a first-degree relative 
    Venous thromboembolism 15 (1.9%) 29 (10.4) 12 (2.3%) < .0001 
    Atherothrombosis 96 (12.1%) 46 (16.5%) 53 (10.3%) .043 
Hyperlipidemia 
    Hypercholesterolemia 42 (5.3%) 13 (4.7%) 31 (6.0%) .71 
    Hypertriglyceridemia 34 (4.3%) 11 (3.9%) 27 (5.2%) .64 
Varicose veins 187 (23.5%) 58 (20.8%) 117 (22.6%) .65 
Hormonal contraception, n (%) 
    Oral, estroprogestative 38 (4.8%) 2 (0.7%) 5 (0.9%) < .0001 
    Oral, progestin only 5 (0.6%) 14 (5.0%) 27 (5.2%) < .0001 
Lipid-lowering drugs  
Follow-up duration, d 3572 (1860) [254-5461] 3457 (1781) [274-5452] 3392 (1893) [206-5449] .023 
Negative groupConstitutional thrombophilia groupaPLAb groupP
796 279 517  
Age, y 30 (5) [17-44] 29 (4) [18-44] 29 (4) [16-41] .21 
Age > 35 y 43 (5.4%) 12 (4.3%) 15 (2.9%) .086 
Body mass index, kg/m2 25.6 (4.5) [15.3-36.1] 25.9 (4.2) [13.5-34.1] 26.0 (4.6) [15.3-37.0] .16 
    > 30 78 (9.8%) 29 (10.4%) 60 (11.6%) .58 
    < 18.5 12 (1.5%) 3 (1.1%) 5 (1%) .66 
Ethnicity    .87 
    White 753 (94.6%) 264 (94.6%) 489 (94.6%)  
    European 647 (81.3%) 227 (81.4%) 420 (81.2%)  
    North African 106 (13.3%) 37 (13.2%) 69 (13.4%)  
    Black African 36 (4.5%) 12 (4.3%) 22 (4.2%)  
    Asian 7 (0.9%) 3 (1.1%) 6 (1.2%)  
Pregnancy loss subtype     
    Embryonic at < 10 WG 483 (60.7%) 93 (33.3%) 206 (39.8%) < .0001 
    Fetal at ≥ 10 WG 313 (39.3%) 186 (66.6%) 311 (60.2%)  
    Primary 549 (68.9%) 185 (66.3%) 342 (66.1%) .49 
    Secondary 247 (31.1%) 94 (33.7%) 175 (33.9%)  
Inflammatory disease 7 (0.9%) 4 (1.4%) 32 (6.2%) < .0001 
Current smokers 83 (10.4%) 30 (10.8%) 50 (9.7%) .89 
Hypertension 19 (2.4%) 8 (2.9%) 17 (3.3%) .62 
Positive history in a first-degree relative 
    Venous thromboembolism 15 (1.9%) 29 (10.4) 12 (2.3%) < .0001 
    Atherothrombosis 96 (12.1%) 46 (16.5%) 53 (10.3%) .043 
Hyperlipidemia 
    Hypercholesterolemia 42 (5.3%) 13 (4.7%) 31 (6.0%) .71 
    Hypertriglyceridemia 34 (4.3%) 11 (3.9%) 27 (5.2%) .64 
Varicose veins 187 (23.5%) 58 (20.8%) 117 (22.6%) .65 
Hormonal contraception, n (%) 
    Oral, estroprogestative 38 (4.8%) 2 (0.7%) 5 (0.9%) < .0001 
    Oral, progestin only 5 (0.6%) 14 (5.0%) 27 (5.2%) < .0001 
Lipid-lowering drugs  
Follow-up duration, d 3572 (1860) [254-5461] 3457 (1781) [274-5452] 3392 (1893) [206-5449] .023 

Quantitative data are given as median (interquartile range) [range] and qualitative data as number (percentage) values.

WG indicates weeks of gestation.

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