Comparison of rates of vascular events between women positive for aPLAb or Leiden mutation (constitutional thrombophilia) and those negative for thrombophilias (negative)
| Outcomes . | Group . | n (%) . | P . | Annualized rates, % (range) . | aHR* . | P† . |
|---|---|---|---|---|---|---|
| PE | < .0001 | .0005 | ||||
| Negative | 9 (1.13) | 0.12 (0.05-0.22) | Reference | |||
| Constitutional thrombophilia | 3 (1.08) | 0.11 (0.02-0.33) | 0.98 (0.26-3.61) | .97 | ||
| aPLAb | 20 (3.87) | 0.43 (0.26-0.66) | 1.93 (1.30-2.87) | .001 | ||
| DVT | < .0001 | < .0001 | ||||
| Negative | 33 (4.15) | 0.43 (0.30-0.61) | Reference | |||
| Constitutional thrombophilia | 15 (5.38) | 0.57 (0.32-0.93) | 1.33 (0.73-2.46) | .35 | ||
| aPLAb | 68 (13.15) | 1.46 (1.15-1.82) | 1.85 (1.50-2.28) | < .0001 | ||
| Proximal DVT | < .0001 | < .0001 | ||||
| Negative | 17 (2.14) | 0.22 (0.13-0.36) | Reference | |||
| Constitutional thrombophilia | 7 (2.51) | 0.27 (0.11-0.54) | 1.21 (0.50-2.92) | .67 | ||
| aPLAb | 38 (7.35) | 0.82 (0.58-1.11) | 1.93 1.45-2.58) | < .0001 | ||
| Distal DVT | .0009 | .0004 | ||||
| Negative | 16 (2.01) | 0.21 (0.12-0.35) | Reference | |||
| Constitutional thrombophilia | 8 (2.87) | 0.31 (0.13-0.60) | 1.47 (0.63-3.44) | .38 | ||
| aPLAb | 30 (5.80) | 0.65 (0.44-0.91) | 1.76 (1.30-2.38) | .0003 | ||
| Superficial vein thrombosis | .0085 | .021 | ||||
| Negative | 11 (1.38) | 0.14 (0.07-0.26) | Reference | |||
| Constitutional thrombophilia | 9 (3.23) | 0.34 (0.16-0.65) | 2.36 (0.97-5.71) | .06 | ||
| aPLAb | 21 (4.06) | 0.44 (0.28-0.68) | 1.78 (1.23-2.56) | .002 | ||
| TIA | .19 | .165 | ||||
| Negative | 4 (0.50) | 0.05 (0.01-0.14) | Reference | |||
| Constitutional thrombophilia | 4 (1.43) | 0.15 (0.04-0.39) | 2.95 0.74-11.8) | .13 | ||
| aPLAb | 7 (1.35) | 0.15 (0.06-0.31) | 1.68 (0.91-3.12) | .096 | ||
| Stroke | .039 | .059 | ||||
| Negative | 3 (0.38) | 0.04 (0.01-0.12) | Reference | |||
| Constitutional thrombophilia | 1 (0.36) | 0.04 (0.01-0.21) | 0.97 (0.10-9.26) | .97 | ||
| aPLAb | 8 (1.55) | 0.17 (0.07-0.34) | 2.10 (1.08-4.08) | .028 | ||
| TIA or stroke | .021 | .014 | ||||
| Negative | 7 (0.88) | 0.09 (0.04-0.19) | Reference | |||
| Constitutional thrombophilia | 5 (1.79) | 0.19 (0.06-0.44) | 2.09 (0.66-6.58) | .21 | ||
| aPLAb | 15 (2.90) | 0.32 (0.18-0.53) | 1.87 (1.20-2.93) | .006 |
| Outcomes . | Group . | n (%) . | P . | Annualized rates, % (range) . | aHR* . | P† . |
|---|---|---|---|---|---|---|
| PE | < .0001 | .0005 | ||||
| Negative | 9 (1.13) | 0.12 (0.05-0.22) | Reference | |||
| Constitutional thrombophilia | 3 (1.08) | 0.11 (0.02-0.33) | 0.98 (0.26-3.61) | .97 | ||
| aPLAb | 20 (3.87) | 0.43 (0.26-0.66) | 1.93 (1.30-2.87) | .001 | ||
| DVT | < .0001 | < .0001 | ||||
| Negative | 33 (4.15) | 0.43 (0.30-0.61) | Reference | |||
| Constitutional thrombophilia | 15 (5.38) | 0.57 (0.32-0.93) | 1.33 (0.73-2.46) | .35 | ||
| aPLAb | 68 (13.15) | 1.46 (1.15-1.82) | 1.85 (1.50-2.28) | < .0001 | ||
| Proximal DVT | < .0001 | < .0001 | ||||
| Negative | 17 (2.14) | 0.22 (0.13-0.36) | Reference | |||
| Constitutional thrombophilia | 7 (2.51) | 0.27 (0.11-0.54) | 1.21 (0.50-2.92) | .67 | ||
| aPLAb | 38 (7.35) | 0.82 (0.58-1.11) | 1.93 1.45-2.58) | < .0001 | ||
| Distal DVT | .0009 | .0004 | ||||
| Negative | 16 (2.01) | 0.21 (0.12-0.35) | Reference | |||
| Constitutional thrombophilia | 8 (2.87) | 0.31 (0.13-0.60) | 1.47 (0.63-3.44) | .38 | ||
| aPLAb | 30 (5.80) | 0.65 (0.44-0.91) | 1.76 (1.30-2.38) | .0003 | ||
| Superficial vein thrombosis | .0085 | .021 | ||||
| Negative | 11 (1.38) | 0.14 (0.07-0.26) | Reference | |||
| Constitutional thrombophilia | 9 (3.23) | 0.34 (0.16-0.65) | 2.36 (0.97-5.71) | .06 | ||
| aPLAb | 21 (4.06) | 0.44 (0.28-0.68) | 1.78 (1.23-2.56) | .002 | ||
| TIA | .19 | .165 | ||||
| Negative | 4 (0.50) | 0.05 (0.01-0.14) | Reference | |||
| Constitutional thrombophilia | 4 (1.43) | 0.15 (0.04-0.39) | 2.95 0.74-11.8) | .13 | ||
| aPLAb | 7 (1.35) | 0.15 (0.06-0.31) | 1.68 (0.91-3.12) | .096 | ||
| Stroke | .039 | .059 | ||||
| Negative | 3 (0.38) | 0.04 (0.01-0.12) | Reference | |||
| Constitutional thrombophilia | 1 (0.36) | 0.04 (0.01-0.21) | 0.97 (0.10-9.26) | .97 | ||
| aPLAb | 8 (1.55) | 0.17 (0.07-0.34) | 2.10 (1.08-4.08) | .028 | ||
| TIA or stroke | .021 | .014 | ||||
| Negative | 7 (0.88) | 0.09 (0.04-0.19) | Reference | |||
| Constitutional thrombophilia | 5 (1.79) | 0.19 (0.06-0.44) | 2.09 (0.66-6.58) | .21 | ||
| aPLAb | 15 (2.90) | 0.32 (0.18-0.53) | 1.87 (1.20-2.93) | .006 |
aHR indicated adjusted hazard ratio (adjustment for age, body mass index, thrombotic familial antecedents, ethnicity, smoking history, hypertension, hypercholesterolemia, hypertriglyceridemia, current oral estro-progestative OC use, current oral progestin-only OC use, varicose veins, embryonic/fetal pregnancy loss, primary/secondary pregnancy loss, and any associated systemic disease).
By log-rank test.