Univariate analysis of transplantation outcomes by donor type
| . | n . | MRD probability, % (95% CI) . | n . | 8/8 MUD probability, % (95% CI) . | n . | 7/8 MUD probability, % (95% CI) . | P* . | 8/8 MUD vs MRD, P† . | 7/8 MUD vs MRD, P† . | 7/8 MUD vs 8/8 MUD, P† . |
|---|---|---|---|---|---|---|---|---|---|---|
| ANC recovery | 621 | 1192 | 406 | |||||||
| @ 28 d | 96 (94-97) | 93 (92-95) | 92 (89-95) | .01 | .008 | .02 | .59 | |||
| @ 100 d | 97 (96-99) | 96 (94-97) | 95 (93-97) | .03 | .02 | .04 | .65 | |||
| Platelet recovery | 615 | 1183 | 398 | |||||||
| @ 60 d | 87 (85-90) | 83 (81-86) | 81 (78-85) | .02 | .02 | .01 | .40 | |||
| @ 100 d | 89 (86-91) | 85 (83-87) | 85 (81-88) | .05 | .02 | .05 | .76 | |||
| Acute GVHD grade B-D | 622 | 1192 | 406 | |||||||
| @ 100 d | 33 (29-36) | 51 (48-54) | 53 (48-58) | < .001 | < .001 | < .001 | .51 | |||
| Acute GVHD grade C-D | 623 | 1193 | 406 | |||||||
| @ 100 d | 12 (10-15) | 25 (23-28) | 31 (27-36) | < .001 | < .001 | < .001 | .01 | |||
| Chronic GVHD | 608 | 1150 | 394 | |||||||
| @ 1 y | 39 (35-43) | 45 (42-48) | 43 (38-48) | .03 | .008 | .19 | .40 | |||
| @ 3 y | 44 (40-48) | 48 (45-51) | 46 (41-51) | .29 | .11 | .43 | .63 | |||
| TRM | 604 | 1157 | 395 | |||||||
| @ 1 y | 18 (15-21) | 21 (19-23) | 32 (27-37) | < .001 | .08 | < .001 | < .001 | |||
| @ 3 y | 25 (22-29) | 28 (25-31) | 36 (32-41) | .001 | .23 | < .001 | .001 | |||
| Relapse | 604 | 1157 | 395 | |||||||
| @ 1 y | 32 (29-36) | 35 (32-37) | 27 (23-32) | .02 | .34 | .09 | .005 | |||
| @ 3 y | 39 (35-43) | 38 (35-41) | 32 (28-37) | .06 | .65 | .02 | .04 | |||
| LFS | 604 | 1157 | 395 | .09‡ | ||||||
| @ 1 y | 50 (45-54) | 44 (41-47) | 40 (36-45) | .013 | .02 | .004 | .22 | |||
| @ 3 y | 35 (31-39) | 34 (31-36) | 31 (26-35) | .37 | .46 | .16 | .35 | |||
| Survival | 624 | 1193 | 406 | .01‡ | ||||||
| @ 1 y | 55 (51-59) | 52 (50-55) | 45 (40-50) | .004 | .28 | .001 | .008 | |||
| @ 3 y | 39 (35-43) | 37 (34-40) | 34 (30-39) | .28 | .37 | .11 | .31 |
| . | n . | MRD probability, % (95% CI) . | n . | 8/8 MUD probability, % (95% CI) . | n . | 7/8 MUD probability, % (95% CI) . | P* . | 8/8 MUD vs MRD, P† . | 7/8 MUD vs MRD, P† . | 7/8 MUD vs 8/8 MUD, P† . |
|---|---|---|---|---|---|---|---|---|---|---|
| ANC recovery | 621 | 1192 | 406 | |||||||
| @ 28 d | 96 (94-97) | 93 (92-95) | 92 (89-95) | .01 | .008 | .02 | .59 | |||
| @ 100 d | 97 (96-99) | 96 (94-97) | 95 (93-97) | .03 | .02 | .04 | .65 | |||
| Platelet recovery | 615 | 1183 | 398 | |||||||
| @ 60 d | 87 (85-90) | 83 (81-86) | 81 (78-85) | .02 | .02 | .01 | .40 | |||
| @ 100 d | 89 (86-91) | 85 (83-87) | 85 (81-88) | .05 | .02 | .05 | .76 | |||
| Acute GVHD grade B-D | 622 | 1192 | 406 | |||||||
| @ 100 d | 33 (29-36) | 51 (48-54) | 53 (48-58) | < .001 | < .001 | < .001 | .51 | |||
| Acute GVHD grade C-D | 623 | 1193 | 406 | |||||||
| @ 100 d | 12 (10-15) | 25 (23-28) | 31 (27-36) | < .001 | < .001 | < .001 | .01 | |||
| Chronic GVHD | 608 | 1150 | 394 | |||||||
| @ 1 y | 39 (35-43) | 45 (42-48) | 43 (38-48) | .03 | .008 | .19 | .40 | |||
| @ 3 y | 44 (40-48) | 48 (45-51) | 46 (41-51) | .29 | .11 | .43 | .63 | |||
| TRM | 604 | 1157 | 395 | |||||||
| @ 1 y | 18 (15-21) | 21 (19-23) | 32 (27-37) | < .001 | .08 | < .001 | < .001 | |||
| @ 3 y | 25 (22-29) | 28 (25-31) | 36 (32-41) | .001 | .23 | < .001 | .001 | |||
| Relapse | 604 | 1157 | 395 | |||||||
| @ 1 y | 32 (29-36) | 35 (32-37) | 27 (23-32) | .02 | .34 | .09 | .005 | |||
| @ 3 y | 39 (35-43) | 38 (35-41) | 32 (28-37) | .06 | .65 | .02 | .04 | |||
| LFS | 604 | 1157 | 395 | .09‡ | ||||||
| @ 1 y | 50 (45-54) | 44 (41-47) | 40 (36-45) | .013 | .02 | .004 | .22 | |||
| @ 3 y | 35 (31-39) | 34 (31-36) | 31 (26-35) | .37 | .46 | .16 | .35 | |||
| Survival | 624 | 1193 | 406 | .01‡ | ||||||
| @ 1 y | 55 (51-59) | 52 (50-55) | 45 (40-50) | .004 | .28 | .001 | .008 | |||
| @ 3 y | 39 (35-43) | 37 (34-40) | 34 (30-39) | .28 | .37 | .11 | .31 |