Table 1 Clinical and genetic... | American Society of Hematology

Table 1

Clinical and genetic characteristics of the consecutive series of newly diagnosed and previously untreated CLL patients

	All (N = 306)		BIRC3 disrupted (n = 13)		BIRC3 WT (n = 293)		P
	n	%	n	%	n	%	P
Age > 65 y	200	65	10	77	190	65	.553
Male	169	55	8	61	161	55	.779
CLL phenotypic score > 3	306	100	13	100	293	100	1.000
Rai stage III-IV	33	11	4	31	29	10	.040
IGHV identity ≥ 98%	98	32	10	77	88	30	.001
TP53 disruption	31	10	0	0	31	11	.376
NOTCH1 mutations	33	11	2	15	31	11	.641
SF3B1 mutations	13	4	2	15	16	5	.173
11q22-q23 deletion	18	6	9	69	9	3	< .001
Trisomy 12	59	19	4	31	55	19	.285
13q14 deletion	160	52	9	69	151	293	.263
Normal FISH	91	30	0	0	91	31	.012

	All (N = 306)		BIRC3 disrupted (n = 13)		BIRC3 WT (n = 293)		P
	n	%	n	%	n	%	P
Age > 65 y	200	65	10	77	190	65	.553
Male	169	55	8	61	161	55	.779
CLL phenotypic score > 3	306	100	13	100	293	100	1.000
Rai stage III-IV	33	11	4	31	29	10	.040
IGHV identity ≥ 98%	98	32	10	77	88	30	.001
TP53 disruption	31	10	0	0	31	11	.376
NOTCH1 mutations	33	11	2	15	31	11	.641
SF3B1 mutations	13	4	2	15	16	5	.173
11q22-q23 deletion	18	6	9	69	9	3	< .001
Trisomy 12	59	19	4	31	55	19	.285
13q14 deletion	160	52	9	69	151	293	.263
Normal FISH	91	30	0	0	91	31	.012

WT indicates wild-type.