Clinical and genetic characteristics of the fludarabine-refractory CLL cohort
| . | All (N = 49) . | BIRC3 disrupted (n = 12) . | BIRC3 WT (n = 37) . | P . | |||
|---|---|---|---|---|---|---|---|
| N . | % . | N . | % . | N . | % . | ||
| Age > 65 y | 36 | 73 | 8 | 67 | 28 | 75 | .708 |
| Male | 31 | 63 | 7 | 58 | 24 | 65 | .738 |
| CLL phenotypic score > 3 | 49 | 100 | 12 | 100 | 37 | 100 | 1.000 |
| Rai stage III-IV | 28 | 57 | 8 | 67 | 20 | 54 | .443 |
| Treatment regimen at refractoriness | .499 | ||||||
| FCR | 17 | 35 | 5 | 42 | 12 | 32 | |
| FR | 2 | 4 | 0 | 0 | 2 | 5 | |
| FC | 14 | 29 | 2 | 17 | 12 | 32 | |
| F | 16 | 33 | 5 | 42 | 11 | 30 | |
| IGHV identity ≥ 98% | 39 | 80 | 10 | 82 | 29 | 78 | 1.000 |
| TP53 disruption | 17 | 35 | 0 | 0 | 17 | 37 | .004 |
| NOTCH1 mutations | 12 | 24 | 3 | 25 | 9 | 24 | 1.000 |
| SF3B1 mutations | 12 | 24 | 2 | 17 | 7 | 19 | 1.000 |
| 11q22-q23 deletion | 13 | 26 | 7 | 53 | 6 | 16 | .008 |
| Trisomy 12 | 14 | 29 | 3 | 25 | 11 | 30 | 1.000 |
| 13q14 deletion | 28 | 57 | 7 | 58 | 21 | 57 | 1.000 |
| Normal FISH | 6 | 12 | 1 | 8 | 5 | 13 | 1.000 |
| . | All (N = 49) . | BIRC3 disrupted (n = 12) . | BIRC3 WT (n = 37) . | P . | |||
|---|---|---|---|---|---|---|---|
| N . | % . | N . | % . | N . | % . | ||
| Age > 65 y | 36 | 73 | 8 | 67 | 28 | 75 | .708 |
| Male | 31 | 63 | 7 | 58 | 24 | 65 | .738 |
| CLL phenotypic score > 3 | 49 | 100 | 12 | 100 | 37 | 100 | 1.000 |
| Rai stage III-IV | 28 | 57 | 8 | 67 | 20 | 54 | .443 |
| Treatment regimen at refractoriness | .499 | ||||||
| FCR | 17 | 35 | 5 | 42 | 12 | 32 | |
| FR | 2 | 4 | 0 | 0 | 2 | 5 | |
| FC | 14 | 29 | 2 | 17 | 12 | 32 | |
| F | 16 | 33 | 5 | 42 | 11 | 30 | |
| IGHV identity ≥ 98% | 39 | 80 | 10 | 82 | 29 | 78 | 1.000 |
| TP53 disruption | 17 | 35 | 0 | 0 | 17 | 37 | .004 |
| NOTCH1 mutations | 12 | 24 | 3 | 25 | 9 | 24 | 1.000 |
| SF3B1 mutations | 12 | 24 | 2 | 17 | 7 | 19 | 1.000 |
| 11q22-q23 deletion | 13 | 26 | 7 | 53 | 6 | 16 | .008 |
| Trisomy 12 | 14 | 29 | 3 | 25 | 11 | 30 | 1.000 |
| 13q14 deletion | 28 | 57 | 7 | 58 | 21 | 57 | 1.000 |
| Normal FISH | 6 | 12 | 1 | 8 | 5 | 13 | 1.000 |
WT indicates wild-type; FCR, fludarabine, cyclophosphamide, rituximab; FR, fludarabine, rituximab; FC, fludarabine, cyclophosphamide; and F, fludarabine.