Univariate and multivariate analysis for OS in newly diagnosed and previously untreated CLL patients
| Characteristic . | Events . | Total . | OS, y . | Univariate analysis . | Multivariate analysis*†‡ . | Internal bootstrapping validation . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bootstrap parameters, mean . | Bootstrap selection, % . | ||||||||||||||||
| Median . | LCI . | UCI . | HR . | LCI . | UCI . | P . | HR . | LCI . | UCI . | P . | HR . | LCI . | UCI . | ||||
| BIRC3 WT | 69 | 293 | NR | 85% | |||||||||||||
| BIRC3 disruption | 9 | 13 | 3.1 | 0 | 6.7 | 5.09 | 2.52 | 10.28 | < .001 | 3.04 | 1.21 | 7.61 | .017 | 3.90 | 1.32 | 13.17 | |
| Age ≤ 65 y | 13 | 106 | NR | 100% | |||||||||||||
| Age > 65 y | 65 | 200 | 8.5 | 4.6 | 12.4 | 3.57 | 1.95 | 6.52 | < .001 | 3.88 | 2.08 | 7.22 | < .001 | 4.41 | 2.21 | 8.87 | |
| Rai stage 0-II | 56 | 273 | NR | 97% | |||||||||||||
| Rai stage III-IV | 22 | 33 | 2.7 | 0.6 | 4.9 | 5.44 | 3.31 | 8.97 | < .001 | 3.10 | 1.72 | 5.59 | < .001 | 3.44 | 1.83 | 6.47 | |
| IGHV identity < 98% | 42 | 208 | NR | 33% | |||||||||||||
| IGHV identity ≥ 98% | 36 | 98 | 11.7 | 3.0 | 20.4 | 2.03 | 1.29 | 3.18 | .002 | 1.24 | 0.72 | 2.12 | .426 | 1.31 | 0.75 | 2.28 | |
| No 11q22-q23 deletion | 67 | 288 | NR | 57% | |||||||||||||
| 11q22-q23 deletion | 11 | 18 | 3.1 | 0.8 | 5.4 | 4.08 | 2.14 | 7.77 | < .001 | 2.18 | 0.85 | 5.62 | .105 | 2.51 | 0.85 | 5.64 | |
| TP53 WT | 61 | 275 | NR | 99% | |||||||||||||
| TP53 disruption | 17 | 31 | 2.9 | 0.6 | 5.3 | 3.85 | 2.23 | 6.65 | < .001 | 4.97 | 2.75 | 8.97 | < .001 | 5.30 | 2.84 | 9.92 | |
| NOTCH1 WT | 63 | 273 | NR | 74% | |||||||||||||
| NOTCH1 mutated | 15 | 33 | 3.3 | 1.2 | 14.3 | 2.15 | 1.22 | 3.79 | .007 | 2.08 | 1.04 | 4.16 | .038 | 2.31 | 1.13 | 4.76 | |
| SF3B1 WT | 71 | 288 | NR | 71% | |||||||||||||
| SF3B1 mutated | 7 | 18 | 2.5 | 1.7 | 3.3 | 3.29 | 1.50 | 7.21 | .003 | 2.49 | 1.08 | 5.72 | .032 | 2.94 | 1.20 | 7.35 | |
| Characteristic . | Events . | Total . | OS, y . | Univariate analysis . | Multivariate analysis*†‡ . | Internal bootstrapping validation . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bootstrap parameters, mean . | Bootstrap selection, % . | ||||||||||||||||
| Median . | LCI . | UCI . | HR . | LCI . | UCI . | P . | HR . | LCI . | UCI . | P . | HR . | LCI . | UCI . | ||||
| BIRC3 WT | 69 | 293 | NR | 85% | |||||||||||||
| BIRC3 disruption | 9 | 13 | 3.1 | 0 | 6.7 | 5.09 | 2.52 | 10.28 | < .001 | 3.04 | 1.21 | 7.61 | .017 | 3.90 | 1.32 | 13.17 | |
| Age ≤ 65 y | 13 | 106 | NR | 100% | |||||||||||||
| Age > 65 y | 65 | 200 | 8.5 | 4.6 | 12.4 | 3.57 | 1.95 | 6.52 | < .001 | 3.88 | 2.08 | 7.22 | < .001 | 4.41 | 2.21 | 8.87 | |
| Rai stage 0-II | 56 | 273 | NR | 97% | |||||||||||||
| Rai stage III-IV | 22 | 33 | 2.7 | 0.6 | 4.9 | 5.44 | 3.31 | 8.97 | < .001 | 3.10 | 1.72 | 5.59 | < .001 | 3.44 | 1.83 | 6.47 | |
| IGHV identity < 98% | 42 | 208 | NR | 33% | |||||||||||||
| IGHV identity ≥ 98% | 36 | 98 | 11.7 | 3.0 | 20.4 | 2.03 | 1.29 | 3.18 | .002 | 1.24 | 0.72 | 2.12 | .426 | 1.31 | 0.75 | 2.28 | |
| No 11q22-q23 deletion | 67 | 288 | NR | 57% | |||||||||||||
| 11q22-q23 deletion | 11 | 18 | 3.1 | 0.8 | 5.4 | 4.08 | 2.14 | 7.77 | < .001 | 2.18 | 0.85 | 5.62 | .105 | 2.51 | 0.85 | 5.64 | |
| TP53 WT | 61 | 275 | NR | 99% | |||||||||||||
| TP53 disruption | 17 | 31 | 2.9 | 0.6 | 5.3 | 3.85 | 2.23 | 6.65 | < .001 | 4.97 | 2.75 | 8.97 | < .001 | 5.30 | 2.84 | 9.92 | |
| NOTCH1 WT | 63 | 273 | NR | 74% | |||||||||||||
| NOTCH1 mutated | 15 | 33 | 3.3 | 1.2 | 14.3 | 2.15 | 1.22 | 3.79 | .007 | 2.08 | 1.04 | 4.16 | .038 | 2.31 | 1.13 | 4.76 | |
| SF3B1 WT | 71 | 288 | NR | 71% | |||||||||||||
| SF3B1 mutated | 7 | 18 | 2.5 | 1.7 | 3.3 | 3.29 | 1.50 | 7.21 | .003 | 2.49 | 1.08 | 5.72 | .032 | 2.94 | 1.20 | 7.35 | |
WT indicates wild-type; HR, hazard ratio; LCI, 95% lower confidence interval; UCI, 95% upper confidence interval; and NR, not reached.
Shrinkage coefficient, 0.91.
Discrimination: c-index of the original model, 0.788; bias-corrected c-index, 0.776; optimism, 0.012.
Calibration: calibration slope of the original model, 1.000; bias-corrected calibration slope, 0.894; optimism, 0.106.