Population pharmacokinetic parameters of rituximab presented as point estimates with corresponding 95% CIs for basic structural and covariate models and bootstrap-analysis
| Parameter . | Model 1 (basic structural) . | Model 2 (covariate: WT impact on V) . | Model 3 (covariate: SEX impact on Cl) . | Model 4 (covariate: SEX/WT impact on Cl) . | Bootstrap analysis (500 replicates) . |
|---|---|---|---|---|---|
| Objective function | 7715.842 | 7695.438 | 7705.229 | 7689.212 | |
| Δobjective function | −20.40 | −10.61 | −26.63 | ||
| Apparent total clearance, all, mL/h (95% CI)* | 9.43 (8.05-10.81) | 9.42 (8.05-10.79) | 9.55 (9.48-9.61) | ||
| Interindividual variability, %† | 33.17 | 32.71 | |||
| Apparent total clearance, women, mL/h (95% CI)* | 7.77 (6.68-8.86) | 8.21 (7.16-9.26) | |||
| Interindividual variability, %† | 24.19 | 18.60 | |||
| Apparent total clearance, men, mL/h (95% CI)* | 11.90 (9.74-14.06) | 12.68 (10.07-15.30) | |||
| Interindividual variability, %† | 26.85 | 18.60 | |||
| Central volume, L (95% CI)* | 3.88 (3.48-4.28) | 3.88 (3.49-4.27) | 3.88 (3.47-4.28) | 3.87 (3.77-3.97) | 3.92 (3.91-3.94) |
| Interindividual variability, %† | 22.23 | 22.52 | 22.29 | 22.49 | |
| Intercompartmental clearance, mL/h (95% CI)* | 17.2 (9.73-24.67) | 17.2 (11.03-23.37) | 17.1 (12.28-21.92) | 16.3 (10.93-21.67) | 18.78 (18.37-19.19) |
| Interindividual variability, fixed, %† | |||||
| Volume of distribution, L (95% CI)* | 9.61 (8.44-10.78) | 9.82 (8.76-10.88) | 9.60 (8.51-10.69) | 9.45 (8.26-10.64) | 9.61 (8.61-10.9) |
| Interindividual variability, %† | 18.79 | 14.66 | 18.95 | 20.42 | |
| Residual variability, %‡ | 13.49 | 13.23 | 13.45 | 13.30 |
| Parameter . | Model 1 (basic structural) . | Model 2 (covariate: WT impact on V) . | Model 3 (covariate: SEX impact on Cl) . | Model 4 (covariate: SEX/WT impact on Cl) . | Bootstrap analysis (500 replicates) . |
|---|---|---|---|---|---|
| Objective function | 7715.842 | 7695.438 | 7705.229 | 7689.212 | |
| Δobjective function | −20.40 | −10.61 | −26.63 | ||
| Apparent total clearance, all, mL/h (95% CI)* | 9.43 (8.05-10.81) | 9.42 (8.05-10.79) | 9.55 (9.48-9.61) | ||
| Interindividual variability, %† | 33.17 | 32.71 | |||
| Apparent total clearance, women, mL/h (95% CI)* | 7.77 (6.68-8.86) | 8.21 (7.16-9.26) | |||
| Interindividual variability, %† | 24.19 | 18.60 | |||
| Apparent total clearance, men, mL/h (95% CI)* | 11.90 (9.74-14.06) | 12.68 (10.07-15.30) | |||
| Interindividual variability, %† | 26.85 | 18.60 | |||
| Central volume, L (95% CI)* | 3.88 (3.48-4.28) | 3.88 (3.49-4.27) | 3.88 (3.47-4.28) | 3.87 (3.77-3.97) | 3.92 (3.91-3.94) |
| Interindividual variability, %† | 22.23 | 22.52 | 22.29 | 22.49 | |
| Intercompartmental clearance, mL/h (95% CI)* | 17.2 (9.73-24.67) | 17.2 (11.03-23.37) | 17.1 (12.28-21.92) | 16.3 (10.93-21.67) | 18.78 (18.37-19.19) |
| Interindividual variability, fixed, %† | |||||
| Volume of distribution, L (95% CI)* | 9.61 (8.44-10.78) | 9.82 (8.76-10.88) | 9.60 (8.51-10.69) | 9.45 (8.26-10.64) | 9.61 (8.61-10.9) |
| Interindividual variability, %† | 18.79 | 14.66 | 18.95 | 20.42 | |
| Residual variability, %‡ | 13.49 | 13.23 | 13.45 | 13.30 |