CD4+ T-cell subsets in primary immunodeficiencies
| PID . | CD4+ T cells . | Naive CD4+ T cells . | Memory CD4+ T cells . | CXCR5+CD45RA+ CD4+ T cells . | CXCR5+CD45RA− CD4+ T cells . |
|---|---|---|---|---|---|
| IL12RB1 (n = 6) | 40 ± 4.4 | 71 ± 4.7 | 28 ± 4.7 | 1.6 ± 0.46 | 14 ± 2.8 |
| STAT1 (n = 6) | 40* | 41 ± 10 | 56 ± 10 | 3.9 ± 0.68 | 11 ± 2.3 |
| STAT3 (n = 14) | 41 ± 3.1 | 65 ± 3.8 | 33 ± 3.7 | 1.5 ± 0.29 (n = 11) | 8.7 ± 1.6 (n = 11) |
| TYK2 (n = 2) | 41* | 53 ± 24 | 43 ± 27 | 2.8 ± 1.2 | 15 ± 5.4 |
| Controls | 43 ± 1.4 (n = 54) | 39 ± 1.7 (n = 70) | 59 ± 1.7 (n = 70) | 2.8 ± 0.24 (n = 61) | 15 ± 1.1 (n = 61) |
| PID . | CD4+ T cells . | Naive CD4+ T cells . | Memory CD4+ T cells . | CXCR5+CD45RA+ CD4+ T cells . | CXCR5+CD45RA− CD4+ T cells . |
|---|---|---|---|---|---|
| IL12RB1 (n = 6) | 40 ± 4.4 | 71 ± 4.7 | 28 ± 4.7 | 1.6 ± 0.46 | 14 ± 2.8 |
| STAT1 (n = 6) | 40* | 41 ± 10 | 56 ± 10 | 3.9 ± 0.68 | 11 ± 2.3 |
| STAT3 (n = 14) | 41 ± 3.1 | 65 ± 3.8 | 33 ± 3.7 | 1.5 ± 0.29 (n = 11) | 8.7 ± 1.6 (n = 11) |
| TYK2 (n = 2) | 41* | 53 ± 24 | 43 ± 27 | 2.8 ± 1.2 | 15 ± 5.4 |
| Controls | 43 ± 1.4 (n = 54) | 39 ± 1.7 (n = 70) | 59 ± 1.7 (n = 70) | 2.8 ± 0.24 (n = 61) | 15 ± 1.1 (n = 61) |
Values are mean ± SEM percentage.
PID indicates primary immunodeficiency.
Analysis was only performed on 1 patient.