Table 5

CLL3/CLL8(FCR) comparison: multivariate prognostic factor analysis (Cox backward; n = 234)

End pointVariablePHRLower CLUpper CL
PFS IGHV unfavorable < .001 3.81 2.39 6.05 
 Treatment CLL8(FCR) .004 1.79 1.21 2.65 
TTRT IGHV unfavorable < .001 3.88 2.22 6.77 
OS IGHV unfavorable .001 3.23 1.62 6.44 
 Binet stage B .083 5.85 0.79 43.1 
 Binet stage C .014 12.62 1.69 94.42 
 Age (y) .017 1.053 1.009 1.098 
End pointVariablePHRLower CLUpper CL
PFS IGHV unfavorable < .001 3.81 2.39 6.05 
 Treatment CLL8(FCR) .004 1.79 1.21 2.65 
TTRT IGHV unfavorable < .001 3.88 2.22 6.77 
OS IGHV unfavorable .001 3.23 1.62 6.44 
 Binet stage B .083 5.85 0.79 43.1 
 Binet stage C .014 12.62 1.69 94.42 
 Age (y) .017 1.053 1.009 1.098 

Covariates considered for all end points were treatment CLL8(FCR) vs CLL3; FISH karyotype (11q-, +12, 13q- single, all other categories pooled); IGHV unfavorable vs favorable; Binet stage A, B, C; leukocyte count > 50/nL vs less; and age. Only covariates remaining in the final models are listed.

HR indicates hazard ratio.

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