Microarray analyses of myeloma patient samples confirm down-regulation of GLUT3 and up-regulation of GLUT8 and GLUT11
| Isoform . | Study title* . | Probe set ID . | Fold change . | P† . | Samples compared‡ . |
|---|---|---|---|---|---|
| GLUT3 | Zhan myeloma | M20681_at | −3.219 | 2.13 × 10−10 | MM (74) vs normal PCs from tonsil (7) and bone marrow (37) |
| GLUT3 | Zhan myeloma 3 | 202498_s_at | −2.36 | 3.00 × 10−03 | Smoldering MM (12) vs normal PCs from bone marrow (22) |
| GLUT3 | Zhan myeloma 3 | 202499_s_at | −2.125 | .015 | Smoldering MM (12) vs normal PCs from bone marrow (22) |
| GLUT8 | Zhan myeloma 3 | 239426_at | 1.382 | .05 | Smoldering MM (12) vs normal PCs from bone marrow (22) |
| GLUT11 | Mattioli myeloma | 221262_s_at | 1.855 | 3.00 × 10−03 | MM (39) vs MGUS (7) and plasma cell leukemia (6) |
| GLUT11 | Mulligan myeloma | 221262_s_at | 1.565 | 5.95 × 10−03 | MM patients: dexamethasone nonresponders (42) vs responders (28) |
| GLUT1 | Zhan myeloma 3 | 201250_s_at | 1.858 | 5.87 × 10−04 | Smoldering MM (12) vs normal PCs from bone marrow (22) |
| GLUT1 | Zhan myeloma 3 | 201249_at | −1.000 | .5 | Smoldering MM (12) vs normal PCs from bone marrow (22) |
| Isoform . | Study title* . | Probe set ID . | Fold change . | P† . | Samples compared‡ . |
|---|---|---|---|---|---|
| GLUT3 | Zhan myeloma | M20681_at | −3.219 | 2.13 × 10−10 | MM (74) vs normal PCs from tonsil (7) and bone marrow (37) |
| GLUT3 | Zhan myeloma 3 | 202498_s_at | −2.36 | 3.00 × 10−03 | Smoldering MM (12) vs normal PCs from bone marrow (22) |
| GLUT3 | Zhan myeloma 3 | 202499_s_at | −2.125 | .015 | Smoldering MM (12) vs normal PCs from bone marrow (22) |
| GLUT8 | Zhan myeloma 3 | 239426_at | 1.382 | .05 | Smoldering MM (12) vs normal PCs from bone marrow (22) |
| GLUT11 | Mattioli myeloma | 221262_s_at | 1.855 | 3.00 × 10−03 | MM (39) vs MGUS (7) and plasma cell leukemia (6) |
| GLUT11 | Mulligan myeloma | 221262_s_at | 1.565 | 5.95 × 10−03 | MM patients: dexamethasone nonresponders (42) vs responders (28) |
| GLUT1 | Zhan myeloma 3 | 201250_s_at | 1.858 | 5.87 × 10−04 | Smoldering MM (12) vs normal PCs from bone marrow (22) |
| GLUT1 | Zhan myeloma 3 | 201249_at | −1.000 | .5 | Smoldering MM (12) vs normal PCs from bone marrow (22) |
PCs indicates plasma cells; and MGUS, monoclonal gammopathy of undetermined significance.
Oncomine (Compendia Bioscience) was used for analysis and visualization.
P values are from Oncomine where possible or represent results of 1-tailed, unpaired t tests between 2 clinical groups where values are not available.
Numbers in parentheses represent the number of samples in each clinical group.