Treatment arms and drug dosages for toxicity
| Induction, eight 3-wk cycles . | Bortezomib, 1.3 mg/m2, days 1, 4, 8, 11 . | Dexamethasone, 40 mg, days 1, 8, 15 . | Cyclophosphamide, 500 mg/m2,* days 1, 8 . | Lenalidomide, days 1-14 . |
|---|---|---|---|---|
| VDCR | ✓ | ✓ | ✓ | ✓ (15 mg) |
| VDR | ✓ | ✓ | ✓ (25 mg) | |
| VDC | ✓ | ✓ | ✓ | |
| VDC-mod | ✓ | ✓ | ✓ (+day 15) | |
| Maintenance (four 6-wk cycles) | Bortezomib 1.3 mg/m2 (days 1, 8, 15, 22) | |||
| Induction, eight 3-wk cycles . | Bortezomib, 1.3 mg/m2, days 1, 4, 8, 11 . | Dexamethasone, 40 mg, days 1, 8, 15 . | Cyclophosphamide, 500 mg/m2,* days 1, 8 . | Lenalidomide, days 1-14 . |
|---|---|---|---|---|
| VDCR | ✓ | ✓ | ✓ | ✓ (15 mg) |
| VDR | ✓ | ✓ | ✓ (25 mg) | |
| VDC | ✓ | ✓ | ✓ | |
| VDC-mod | ✓ | ✓ | ✓ (+day 15) | |
| Maintenance (four 6-wk cycles) | Bortezomib 1.3 mg/m2 (days 1, 8, 15, 22) | |||
V indicates bortezomib; D, dexamethasone; R, lenalidomide; C, cyclophosphamide; and VDC-mod, as in VDC plus a day 15 dose of C.
Cyclophosphamide was given as a single oral dose, rounded to the nearest 50 mg.