Multivariate Cox proportional hazards regression models testing the prognostic value of SNP-A chromosome 7 findings in MDS and CMML
| MDS multivariate Cox model (n = 274) . | CMML multivariate Cox model (n = 70) . | ||||
|---|---|---|---|---|---|
| . | P . | HR (95% CI) . | . | P . | HR (95% CI) . |
| BM blasts* | ≤ .001 | 1.8 (1.3-2.4) | BM blasts > 10% | .01 | 10.4 (2.6-41.4) |
| Presence of blasts in PB | .01 | 10.3 (2.5-42.2) | |||
| No. of cytopenias† | .13 | 1.7 (0.8-3.4) | Lymphocyte count > 2.5 × 109/L | .6 | 0.7 (0.2-2.7) |
| 7q LOH SNP-A category‡ | ≤ .001 | 4.5 (3.1-6.7) | Hemoglobin level < 12 g/dL | .4 | 1.7 (0.4-8) |
| Presence of a UPD(7q) | .1 | 4.4 (0.8-16) | |||
| MDS multivariate Cox model (n = 274) . | CMML multivariate Cox model (n = 70) . | ||||
|---|---|---|---|---|---|
| . | P . | HR (95% CI) . | . | P . | HR (95% CI) . |
| BM blasts* | ≤ .001 | 1.8 (1.3-2.4) | BM blasts > 10% | .01 | 10.4 (2.6-41.4) |
| Presence of blasts in PB | .01 | 10.3 (2.5-42.2) | |||
| No. of cytopenias† | .13 | 1.7 (0.8-3.4) | Lymphocyte count > 2.5 × 109/L | .6 | 0.7 (0.2-2.7) |
| 7q LOH SNP-A category‡ | ≤ .001 | 4.5 (3.1-6.7) | Hemoglobin level < 12 g/dL | .4 | 1.7 (0.4-8) |
| Presence of a UPD(7q) | .1 | 4.4 (0.8-16) | |||
HR indicates hazard ratio; BM, bone marrow; PB, peripheral blood; SNP-A, single nucleotide polymorphism array; and CI, confidence interval.
Three BM blasts categories according to the percentage described: < 5; 5-10; and 11-20.
Number of cytopenias categories defined as good (0-1) and poor (2-3). Cytopenias defined as hemoglobin less than 10 g/dL, absolute neutrophil count less than 1.8 × 109/L, and platelets less than 100 × 109/L.
7q LOH SNP-A category defined as good, no deletion; intermediate, monosomy 7; and poor, partial deletion involving 7q.