Laboratory evaluation of the 3 patient populations at the time of diagnosis of IPA
| . | Allogeneic HSCT (N = 23) . | AL (N = 22) . | Others* (N = 10) . |
|---|---|---|---|
| Serum GM antigen | |||
| Median (range) | 0.81 (0.02- > 10) | 0.36 (0.07-7.50) | 1.12 (0.06-8.85) |
| No./no. (%) tested ≥ 0.5 | 15/23 (65%) | 9/22 (41%) | 6/10 (60%) |
| BAL GM antigen | |||
| Median (range) | 2.00 (0-9.80) | 1.00 (0.07-6.83) | 4.10 (0.13-6.12) |
| No./no. (%) tested ≥ 0.5 | 9/14 (64%) | 5/9 (56%) | 4/5 (80%) |
| Positive samples, no./no. tested (%)† | |||
| None | 4/19 (21%) | 12/16 (75%) | 1/9 (11%) |
| BA | 12/17 (71%) | 2/11 (18%) | 6/7 (86%) |
| Direct examination only | 5 | 1 | 2 |
| Culture only | 0 | 0 | 0 |
| Direct + culture | 7 | 1 | 4 |
| BAL‡ | 9/17 (53%) | 2/13 (15%) | 5/6 (83%) |
| Direct only | 0 | 1 | 0 |
| Culture only | 3 | 0 | 2 |
| Direct + culture | 6 | 1 | 3 |
| Sputum | 9/12 (75%) | 2/4 (50%) | 4/4 (100%) |
| Direct only | 3 | 1 | 1 |
| Direct + culture | 6 | 1 | 3 |
| . | Allogeneic HSCT (N = 23) . | AL (N = 22) . | Others* (N = 10) . |
|---|---|---|---|
| Serum GM antigen | |||
| Median (range) | 0.81 (0.02- > 10) | 0.36 (0.07-7.50) | 1.12 (0.06-8.85) |
| No./no. (%) tested ≥ 0.5 | 15/23 (65%) | 9/22 (41%) | 6/10 (60%) |
| BAL GM antigen | |||
| Median (range) | 2.00 (0-9.80) | 1.00 (0.07-6.83) | 4.10 (0.13-6.12) |
| No./no. (%) tested ≥ 0.5 | 9/14 (64%) | 5/9 (56%) | 4/5 (80%) |
| Positive samples, no./no. tested (%)† | |||
| None | 4/19 (21%) | 12/16 (75%) | 1/9 (11%) |
| BA | 12/17 (71%) | 2/11 (18%) | 6/7 (86%) |
| Direct examination only | 5 | 1 | 2 |
| Culture only | 0 | 0 | 0 |
| Direct + culture | 7 | 1 | 4 |
| BAL‡ | 9/17 (53%) | 2/13 (15%) | 5/6 (83%) |
| Direct only | 0 | 1 | 0 |
| Culture only | 3 | 0 | 2 |
| Direct + culture | 6 | 1 | 3 |
| Sputum | 9/12 (75%) | 2/4 (50%) | 4/4 (100%) |
| Direct only | 3 | 1 | 1 |
| Direct + culture | 6 | 1 | 3 |
BA indicates bronchial aspirate.
Non-AL patients with no allogeneic HSCT (lymphoma, chronic lymphocytic leukemia, multiple myeloma, myelodysplastic syndrome, hairy cell leukemia).
A total of 21 Aspergillus fumigatus, 2 Aspergillus nidulans, and 2 Aspergillus niger.
Among the 20 patients who had no BAL, 4 had only BA during bronchoscopy (all were positive), 3 had positive sputum, 8 had a bronchoscopy that was not considered for the study because it was not performed within 24 hours of the baseline HRCT, and 5 patients had no bronchoscopy because of poor clinical condition.