Table 1

Univariate analysis of prognostic impact of chromosomal abnormalities on PFS and OS including patients from both study arms

Aberration, yes vs noPatients analyzed, nIncidence, %PFS
OS
Median, moHR [95% CI]Log-rank P3-y KM, %HR [95% CI]Log-rank P
del(8p21) 80 of 344 23.3 27 vs 35 1.3 [1.0-1.8] .096 70 vs 80 1.2 [0.8-2.0] .40 
del(13q14) 171 of 354 48.3 27 vs 39 1.5 [1.2-2.0] .0023† 70 vs 85 2.4 [1.5-3.8] .0001† 
del(13q14) only* 106 of 272 39.0 31 vs 40 1.3 [0.9-1.8] .13 85 vs 87 1.8 [1.0-3.1] .055 
del(17p13) 37 of 350 10.6 18 vs 36 2.5 [1.7-3.7] < .0001† 36 vs 83 4.4 [2.7-7.1] < .0001† 
t(4;14) 50 of 352 14.2 22 vs 36 2.0 [1.4-2.8] .0002† 55 vs 82 2.4 [1.5-4.0] .0003† 
t(11;14) 68 of 354 19.2 39 vs 32 1.0 [0.7-1.3] .8 83 vs 77 0.8 [0.5-1.5] .53 
t(14;16) 6 of 339 1.8 29 vs 35 1.6 [0.7-4.0] .30 83 vs 78 2.3 [0.8-6.3] .11 
+1q21 111 of 344 32.3 27 vs 39 1.7 [1.3-2.3] .0002† 70 vs 82 1.9 [1.2-2.9] .0052† 
+11q23 172 of 344 48.6 36 vs 31 0.9 [0.7-1.2] .45 79 vs 77 0.9 [0.6-1.3] .47 
+19q13 182 of 350 52.0 36 vs 31 0.8 [0.6-1.1] .19 83 vs 73 0.6 [0.4-1.0] .043 
Hyperdiploidy 175 of 354 49.4 35 vs 32 0.9 [0.7-1.2] .54 81 vs 75 0.8 [0.5-1.3] .39 
Aberration, yes vs noPatients analyzed, nIncidence, %PFS
OS
Median, moHR [95% CI]Log-rank P3-y KM, %HR [95% CI]Log-rank P
del(8p21) 80 of 344 23.3 27 vs 35 1.3 [1.0-1.8] .096 70 vs 80 1.2 [0.8-2.0] .40 
del(13q14) 171 of 354 48.3 27 vs 39 1.5 [1.2-2.0] .0023† 70 vs 85 2.4 [1.5-3.8] .0001† 
del(13q14) only* 106 of 272 39.0 31 vs 40 1.3 [0.9-1.8] .13 85 vs 87 1.8 [1.0-3.1] .055 
del(17p13) 37 of 350 10.6 18 vs 36 2.5 [1.7-3.7] < .0001† 36 vs 83 4.4 [2.7-7.1] < .0001† 
t(4;14) 50 of 352 14.2 22 vs 36 2.0 [1.4-2.8] .0002† 55 vs 82 2.4 [1.5-4.0] .0003† 
t(11;14) 68 of 354 19.2 39 vs 32 1.0 [0.7-1.3] .8 83 vs 77 0.8 [0.5-1.5] .53 
t(14;16) 6 of 339 1.8 29 vs 35 1.6 [0.7-4.0] .30 83 vs 78 2.3 [0.8-6.3] .11 
+1q21 111 of 344 32.3 27 vs 39 1.7 [1.3-2.3] .0002† 70 vs 82 1.9 [1.2-2.9] .0052† 
+11q23 172 of 344 48.6 36 vs 31 0.9 [0.7-1.2] .45 79 vs 77 0.9 [0.6-1.3] .47 
+19q13 182 of 350 52.0 36 vs 31 0.8 [0.6-1.1] .19 83 vs 73 0.6 [0.4-1.0] .043 
Hyperdiploidy 175 of 354 49.4 35 vs 32 0.9 [0.7-1.2] .54 81 vs 75 0.8 [0.5-1.3] .39 
*

del(13q14) without the presence of del(17p13) and t(4;14).

†

These numbers retain statistical significant after adjustment of P for multiple testing.

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