Table 3 Comparison between treatment... | American Society of Hematology

Table 3

Comparison between treatment arms with respect to the chromosomal aberrations analyzed

Chromosomal aberration	Treatment arm	PFS			OS
Chromosomal aberration	Treatment arm	Median, mo	HR [95% CI]	Log-rank P	3-y KM, %	HR [95% CI]	Log-rank P
del(8p21)	B vs A	32.7 vs 25.3	0.77 [0.44;1.35]	.37	78 vs 65	0.51 [0.20;1.31]	.16
del(13q14)	B vs A	27.4 vs 25.2	0.81 [0.56;1.18]	.27	81 vs 61	0.62 [0.36;1.04]	.072
del(13q14) only*	B vs A	28.8 vs 31.7	1.08 [0.65;1.78]	.78	88 vs 82	0.82 [0.37;1.84]	.64
del(17p13)	B vs A	26.2 vs 12.0	0.41 [0.19;0.91]	.024	69 vs 17	0.37 [0.14;0.93]	.028
t(4;14)	B vs A	25.3 vs 21.7	0.60 [0.32;1.15]	.12	66 vs 44	0.68 [0.29;1.59]	.37
t(11;14)	B vs A	39.8 vs 35.4	0.73 [0.39;1.37]	.33	87 vs 79	0.62 [0.21;1.79]	.37
+1q21†	B vs A	28.2 vs 23.6	0.76 [0.48;1.18]	.22	77 vs 62	0.58 [0.30;1.12]	.10
+11q23	B vs A	39.3 vs 33.4	0.80 [0.53;1.19]	.27	83 vs 75	0.59 [0.31;1.13]	.11
+19q13	B vs A	38.3 vs 34.8	0.85 [0.57;1.26]	.41	85 vs 80	0.69 [0.36;1.31]	.26
Hyperdiploidy	B vs A	35.7 vs 33.4	0.77 [0.52;1.16]	.21	84 vs 78	0.66 [0.35;1.26]	.21

Chromosomal aberration	Treatment arm	PFS			OS
Chromosomal aberration	Treatment arm	Median, mo	HR [95% CI]	Log-rank P	3-y KM, %	HR [95% CI]	Log-rank P
del(8p21)	B vs A	32.7 vs 25.3	0.77 [0.44;1.35]	.37	78 vs 65	0.51 [0.20;1.31]	.16
del(13q14)	B vs A	27.4 vs 25.2	0.81 [0.56;1.18]	.27	81 vs 61	0.62 [0.36;1.04]	.072
del(13q14) only*	B vs A	28.8 vs 31.7	1.08 [0.65;1.78]	.78	88 vs 82	0.82 [0.37;1.84]	.64
del(17p13)	B vs A	26.2 vs 12.0	0.41 [0.19;0.91]	.024	69 vs 17	0.37 [0.14;0.93]	.028
t(4;14)	B vs A	25.3 vs 21.7	0.60 [0.32;1.15]	.12	66 vs 44	0.68 [0.29;1.59]	.37
t(11;14)	B vs A	39.8 vs 35.4	0.73 [0.39;1.37]	.33	87 vs 79	0.62 [0.21;1.79]	.37
+1q21†	B vs A	28.2 vs 23.6	0.76 [0.48;1.18]	.22	77 vs 62	0.58 [0.30;1.12]	.10
+11q23	B vs A	39.3 vs 33.4	0.80 [0.53;1.19]	.27	83 vs 75	0.59 [0.31;1.13]	.11
+19q13	B vs A	38.3 vs 34.8	0.85 [0.57;1.26]	.41	85 vs 80	0.69 [0.36;1.31]	.26
Hyperdiploidy	B vs A	35.7 vs 33.4	0.77 [0.52;1.16]	.21	84 vs 78	0.66 [0.35;1.26]	.21

Patients carrying t(14;16) were not included in the analysis because of the small sample size (n = 6).

del(13q14) without the presence of del(17p13) and t(4;14).

No statistically significant difference was observed when +1q21 (3 copies) and +1q21 (>3 copies) were analyzed separately.