Multivariate analysis of prognostic impact of chromosomal abnormalities (multivariate Cox PH analysis)
| Variable . | PFS . | OS . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Treatment arm A (n = 180) . | Treatment arm B (n = 170) . | All patients (n = 350) . | Treatment arm A (n = 180) . | Treatment arm B (n = 170) . | All patients (n = 350) . | |||||||
| HR . | P . | HR . | P . | HR . | P . | HR . | P . | HR . | P . | HR . | P . | |
| Treatment arm B | 0.80 | .12 | 0.63 | .048 | ||||||||
| Female sex | 0.89 | .46 | 1.03 | .88 | 0.92 | .56 | 0.84 | .58 | 1.34 | .47 | 1.02 | .92 |
| Age | 0.99 | .41 | 0.99 | .42 | 0.99 | .15 | 0.98 | .18 | 0.99 | .77 | 0.99 | .27 |
| IgG | 1.09 | .78 | 1.20 | .52 | 1.14 | .51 | 1.93 | .15 | 0.88 | .77 | 1.39 | .28 |
| LCD | 0.92 | .80 | 0.46 | .061 | 0.66 | .096 | 1.05 | .92 | 0.09 | .032 | 0.51 | .11 |
| ISS score II | 2.01 | .011 | 0.90 | .71 | 1.27 | .21 | 2.31 | .060 | 1.48 | .45 | 1.78 | .074 |
| ISS score III | 2.24 | .0031 | 1.51 | .20 | 1.89 | .0015 | 3.87 | .0020 | 3.25 | .034 | 3.58 | .0001 |
| Elevated LDH | 0.68 | .16 | 2.42 | .0038 | 1.18 | .39 | 1.10 | .79 | 3.02 | .011 | 1.57 | .084 |
| del(8p21) | 1.17 | .52 | 1.38 | .26 | 1.27 | .17 | 0.98 | .95 | 1.04 | .94 | 0.99 | .96 |
| del(13q14) only | 1.05 | .85 | 1.38 | .23 | 1.24 | .23 | 1.20 | .66 | 1.73 | .26 | 1.52 | .15 |
| del(17p13) | 4.13 | < .0001 | 1.56 | .28 | 2.40 | .0002 | 6.71 | < .0001 | 2.60 | .12 | 4.14 | < .0001 |
| t(4;14) | 1.36 | .34 | 1.53 | .24 | 1.43 | .11 | 1.13 | .77 | 2.31 | .20 | 1.51 | .20 |
| t(11;14) | 1.08 | .80 | 1.08 | .82 | 1.20 | .38 | 0.80 | .62 | 1.75 | .37 | 1.16 | .66 |
| +1q21 (3 copies) | 1.93 | .0061 | 1.55 | .098 | 1.52 | .013 | 2.14 | .040 | 1.43 | .47 | 1.68 | .049 |
| +1q21 (> 3 copies) | 2.23 | .13 | 3.57 | .021 | 2.50 | .011 | 7.13 | .0026 | 2.71 | .27 | 4.62 | .0013 |
| +11q23 | 0.99 | .98 | 1.08 | .80 | 1.12 | .60 | 1.26 | .59 | 1.31 | .58 | 1.38 | .30 |
| +19q13 | 0.53 | .081 | 0.59 | .20 | 0.61 | .066 | 0.33 | .025 | 0.35 | .092 | 0.35 | .0040 |
| Hyperdiploidy | 1.73 | .089 | 1.45 | .36 | 1.51 | .087 | 1.64 | .31 | 2.99 | .092 | 1.99 | .054 |
| Variable . | PFS . | OS . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Treatment arm A (n = 180) . | Treatment arm B (n = 170) . | All patients (n = 350) . | Treatment arm A (n = 180) . | Treatment arm B (n = 170) . | All patients (n = 350) . | |||||||
| HR . | P . | HR . | P . | HR . | P . | HR . | P . | HR . | P . | HR . | P . | |
| Treatment arm B | 0.80 | .12 | 0.63 | .048 | ||||||||
| Female sex | 0.89 | .46 | 1.03 | .88 | 0.92 | .56 | 0.84 | .58 | 1.34 | .47 | 1.02 | .92 |
| Age | 0.99 | .41 | 0.99 | .42 | 0.99 | .15 | 0.98 | .18 | 0.99 | .77 | 0.99 | .27 |
| IgG | 1.09 | .78 | 1.20 | .52 | 1.14 | .51 | 1.93 | .15 | 0.88 | .77 | 1.39 | .28 |
| LCD | 0.92 | .80 | 0.46 | .061 | 0.66 | .096 | 1.05 | .92 | 0.09 | .032 | 0.51 | .11 |
| ISS score II | 2.01 | .011 | 0.90 | .71 | 1.27 | .21 | 2.31 | .060 | 1.48 | .45 | 1.78 | .074 |
| ISS score III | 2.24 | .0031 | 1.51 | .20 | 1.89 | .0015 | 3.87 | .0020 | 3.25 | .034 | 3.58 | .0001 |
| Elevated LDH | 0.68 | .16 | 2.42 | .0038 | 1.18 | .39 | 1.10 | .79 | 3.02 | .011 | 1.57 | .084 |
| del(8p21) | 1.17 | .52 | 1.38 | .26 | 1.27 | .17 | 0.98 | .95 | 1.04 | .94 | 0.99 | .96 |
| del(13q14) only | 1.05 | .85 | 1.38 | .23 | 1.24 | .23 | 1.20 | .66 | 1.73 | .26 | 1.52 | .15 |
| del(17p13) | 4.13 | < .0001 | 1.56 | .28 | 2.40 | .0002 | 6.71 | < .0001 | 2.60 | .12 | 4.14 | < .0001 |
| t(4;14) | 1.36 | .34 | 1.53 | .24 | 1.43 | .11 | 1.13 | .77 | 2.31 | .20 | 1.51 | .20 |
| t(11;14) | 1.08 | .80 | 1.08 | .82 | 1.20 | .38 | 0.80 | .62 | 1.75 | .37 | 1.16 | .66 |
| +1q21 (3 copies) | 1.93 | .0061 | 1.55 | .098 | 1.52 | .013 | 2.14 | .040 | 1.43 | .47 | 1.68 | .049 |
| +1q21 (> 3 copies) | 2.23 | .13 | 3.57 | .021 | 2.50 | .011 | 7.13 | .0026 | 2.71 | .27 | 4.62 | .0013 |
| +11q23 | 0.99 | .98 | 1.08 | .80 | 1.12 | .60 | 1.26 | .59 | 1.31 | .58 | 1.38 | .30 |
| +19q13 | 0.53 | .081 | 0.59 | .20 | 0.61 | .066 | 0.33 | .025 | 0.35 | .092 | 0.35 | .0040 |
| Hyperdiploidy | 1.73 | .089 | 1.45 | .36 | 1.51 | .087 | 1.64 | .31 | 2.99 | .092 | 1.99 | .054 |
Patients with t(14;16) were not included due to the low prevalence of this aberration (n = 6).
LCD indicates light chain disease; and LDH, lactate dehydrogenase.