Table 2 Pediatric AIS patients with ICH... | American Society of Hematology

Table 2

Pediatric AIS patients with ICH during ACT

Case no.	Age, y	Sex	Pre-existing condition	Pre-existing ICH	Treatment at time of ICH	Interval event to ICH	ECASS grade	Change over time	Clinical presentation at time of ICH	Risk factor for bleed	Clinical Outcome
1	15.7	F	Acute myeloid leukemia, Antiphopholipid syndrome	None	UFH	7	HI1	Progression, remained HI1	Asymptomatic then coma due to recurrent AIS and ICH	Abnormal lab: PLT-32, anti–Xa-0.81, HgB-85 APLA ayndrome	Died (fatal catastrophic APLA syndrome with recurrent emboli and bleeds)
2	10.4	M	CHD	None	Warfarin	10	HI2	Regression, HI1	Asymptomatic		Died (cardiac)
3	11.5	M	CHD-S/P heart transplant.	None	LMWH	20			Asymptomatic		Mild neurological deficit
4	11	M	CHD	None	UFH and ASA	6	HI1		Asymptomatic		Severe neurological deficit
5	5.8	M	Vasculitis	None	UFH	9			Asymptomatic		Severe neurological deficit
6	1.5	F	CHD	None	LMWH and Warfarin	9	HI2		Asymptomatic		Severe neurological deficit
7	14.8	M	Hyperlipidemia	None	LMWH	12	HI2		Asymptomatic		Normal
8	2.2	M	CHD after Fontan surgery	Yes	LMWH	26	PH2		Asymptomatic	Abnormal lab: INR-3	Severe neurological deficit
8	2.2	M	CHD after Fontan surgery	ECASS HI1	LMWH	26	PH2		Asymptomatic	Abnormal lab: INR-3	Severe neurological deficit
9	2.6	F	Post varicella vaccine	None	LMWH	13	HI1		Asymptomatic		Moderate neurological deficit
10	7.9	F	Post varicella	None	UFH	4			Facial drop and aphasia		Mild neurological deficit
11	1.4	M	Moya-moya disease	None	UFH and ASA	3	HI1	Progression, HI1	Focal seizure and irritability		Severe neurological deficit
12	2.9	F	CHD after catheterization	None	LMWH and Warfarin	15	HI1		Irritability		Died (cardiac)
13	14	M	CHD after catheterization	None	UFH	2	HI1		Loss of consciousness/coma		Moderate neurological deficit
14	8.9	M	Minor trauma	None	LMWH	10	HI1		Headache and vomiting		Severe neurological deficit

Case no.	Age, y	Sex	Pre-existing condition	Pre-existing ICH	Treatment at time of ICH	Interval event to ICH	ECASS grade	Change over time	Clinical presentation at time of ICH	Risk factor for bleed	Clinical Outcome
1	15.7	F	Acute myeloid leukemia, Antiphopholipid syndrome	None	UFH	7	HI1	Progression, remained HI1	Asymptomatic then coma due to recurrent AIS and ICH	Abnormal lab: PLT-32, anti–Xa-0.81, HgB-85 APLA ayndrome	Died (fatal catastrophic APLA syndrome with recurrent emboli and bleeds)
2	10.4	M	CHD	None	Warfarin	10	HI2	Regression, HI1	Asymptomatic		Died (cardiac)
3	11.5	M	CHD-S/P heart transplant.	None	LMWH	20			Asymptomatic		Mild neurological deficit
4	11	M	CHD	None	UFH and ASA	6	HI1		Asymptomatic		Severe neurological deficit
5	5.8	M	Vasculitis	None	UFH	9			Asymptomatic		Severe neurological deficit
6	1.5	F	CHD	None	LMWH and Warfarin	9	HI2		Asymptomatic		Severe neurological deficit
7	14.8	M	Hyperlipidemia	None	LMWH	12	HI2		Asymptomatic		Normal
8	2.2	M	CHD after Fontan surgery	Yes	LMWH	26	PH2		Asymptomatic	Abnormal lab: INR-3	Severe neurological deficit
8	2.2	M	CHD after Fontan surgery	ECASS HI1	LMWH	26	PH2		Asymptomatic	Abnormal lab: INR-3	Severe neurological deficit
9	2.6	F	Post varicella vaccine	None	LMWH	13	HI1		Asymptomatic		Moderate neurological deficit
10	7.9	F	Post varicella	None	UFH	4			Facial drop and aphasia		Mild neurological deficit
11	1.4	M	Moya-moya disease	None	UFH and ASA	3	HI1	Progression, HI1	Focal seizure and irritability		Severe neurological deficit
12	2.9	F	CHD after catheterization	None	LMWH and Warfarin	15	HI1		Irritability		Died (cardiac)
13	14	M	CHD after catheterization	None	UFH	2	HI1		Loss of consciousness/coma		Moderate neurological deficit
14	8.9	M	Minor trauma	None	LMWH	10	HI1		Headache and vomiting		Severe neurological deficit

M indicates male; and F, female.

Case 8 ACT despite initial ICH administered ACT for cardiac indication (shunt). Patient also had history of femoral vein thrombosis.