Difference (and P value) in adjusted mean FVIII activity (%) by copy numbers of the haplotype and by ABO adjustment for EA men (N = 3671)
| Haplotype . | ABO adjusted . | P . | Difference . |
|---|---|---|---|
| Block 1* | |||
| AT | No | 6 × 10−4 | 3.74 |
| Yes | 2 × 10−4 | 3.89 | |
| TC | No | 7.7 × 10−3 | −3.20 |
| Yes | 7.3 × 10−3 | −3.05 | |
| AC | No | 8 × 10−2 | −2.95 |
| Yes | 2.9 × 10−2 | −3.50 | |
| Block 2* | |||
| TACCAC | No | 9.5 × 10−3 | 2.96 |
| Yes | 1.2 × 10−2 | 2.71 | |
| GCTTTT | No | 1.5 × 10−3 | −4.71 |
| Yes | 2 × 10−4† | −5.24 | |
| GACCTT | No | 7.9 × 10−1 | −0.50 |
| Yes | 9.5 × 10−1 | 0.12 | |
| GACCAC | No | 9.2 × 10−1 | 0.25 |
| Yes | 6.5 × 10−1 | 1.11 | |
| GACCTC | No | 9.8 × 10−1 | 0.07 |
| Yes | 8.2 × 10−1 | 0.79 |
| Haplotype . | ABO adjusted . | P . | Difference . |
|---|---|---|---|
| Block 1* | |||
| AT | No | 6 × 10−4 | 3.74 |
| Yes | 2 × 10−4 | 3.89 | |
| TC | No | 7.7 × 10−3 | −3.20 |
| Yes | 7.3 × 10−3 | −3.05 | |
| AC | No | 8 × 10−2 | −2.95 |
| Yes | 2.9 × 10−2 | −3.50 | |
| Block 2* | |||
| TACCAC | No | 9.5 × 10−3 | 2.96 |
| Yes | 1.2 × 10−2 | 2.71 | |
| GCTTTT | No | 1.5 × 10−3 | −4.71 |
| Yes | 2 × 10−4† | −5.24 | |
| GACCTT | No | 7.9 × 10−1 | −0.50 |
| Yes | 9.5 × 10−1 | 0.12 | |
| GACCAC | No | 9.2 × 10−1 | 0.25 |
| Yes | 6.5 × 10−1 | 1.11 | |
| GACCTC | No | 9.8 × 10−1 | 0.07 |
| Yes | 8.2 × 10−1 | 0.79 |
EA indicates Americans of European descent.
Adjusted for age, BMI, diabetes, hypertension, and ever smoking.