Clinical and laboratory characteristics of patients with hematologic malignancies taking voriconazole, posaconazole, and itraconazole, and a hematologic patient control group not receiving antifungal therapy
| . | Voriconazole (n = 20) . | Posaconazole (n = 8) . | Itraconazole (n = 4) . | Control group (n = 11) . |
|---|---|---|---|---|
| Mean age, y | 55.1 | 54.9 | 49.5 | 56.6 |
| Male sex, % | 10 (50) | 3 (37.5) | 3 (75) | 7 (63.6) |
| Stem cell transplantation, % | 15 (75) | 3 (37.5) | 4 (100) | 10 (90.9) |
| Median antifungal treatment, days (IQR) | 98 (220) | 13 (576) | 587 (1400) | NA |
| Median drug serum concentration (IQR)* | 1.7 (1.8) | 0.24 (1.17) | 1.95 (1.75) | NA |
| Median glomerular filtration rate (IQR)† | 77.5 (43.6) | 92.2(33.8) | 70.8 (45.7) | 74.2 (18.9) |
| Cyclosporine treatment, % | 9 (45) | 2 (25) | 0 | 6 (54.5) |
| Median cyclosporine blood concentration, μg/L (IQR) | 92 (102.5) | 53.5 | NA | 104 (141.5) |
| Median ALP‡ (IQR) | 111 (76.5) | 66 (103) | 120 (138) | 71 (31) |
| Median ALT§ (IQR) | 30 (12.5) | 36 (30) | 70.5 (90) | 20 (18) |
| Median fluoride level‖ (IQR) | 156.5 (96.8) | < 30 (0) | < 30 (28) | < 30 (32) |
| Median no. of radiographic studies (IQR) | 2 (3.5) | 0.5 (1) | 1 (0.25) | 3 (3.5) |
| Median no. of CT scans (IQR) | 1 (1) | 0.5 (1) | 1 (0.25) | 2 (2) |
| Radiographic evidence of periostitis, % | 1 (5) | 0 | 0 | 0 |
| Bone pain, % | 3 (15) | 0 | 0 | 0 |
| . | Voriconazole (n = 20) . | Posaconazole (n = 8) . | Itraconazole (n = 4) . | Control group (n = 11) . |
|---|---|---|---|---|
| Mean age, y | 55.1 | 54.9 | 49.5 | 56.6 |
| Male sex, % | 10 (50) | 3 (37.5) | 3 (75) | 7 (63.6) |
| Stem cell transplantation, % | 15 (75) | 3 (37.5) | 4 (100) | 10 (90.9) |
| Median antifungal treatment, days (IQR) | 98 (220) | 13 (576) | 587 (1400) | NA |
| Median drug serum concentration (IQR)* | 1.7 (1.8) | 0.24 (1.17) | 1.95 (1.75) | NA |
| Median glomerular filtration rate (IQR)† | 77.5 (43.6) | 92.2(33.8) | 70.8 (45.7) | 74.2 (18.9) |
| Cyclosporine treatment, % | 9 (45) | 2 (25) | 0 | 6 (54.5) |
| Median cyclosporine blood concentration, μg/L (IQR) | 92 (102.5) | 53.5 | NA | 104 (141.5) |
| Median ALP‡ (IQR) | 111 (76.5) | 66 (103) | 120 (138) | 71 (31) |
| Median ALT§ (IQR) | 30 (12.5) | 36 (30) | 70.5 (90) | 20 (18) |
| Median fluoride level‖ (IQR) | 156.5 (96.8) | < 30 (0) | < 30 (28) | < 30 (32) |
| Median no. of radiographic studies (IQR) | 2 (3.5) | 0.5 (1) | 1 (0.25) | 3 (3.5) |
| Median no. of CT scans (IQR) | 1 (1) | 0.5 (1) | 1 (0.25) | 2 (2) |
| Radiographic evidence of periostitis, % | 1 (5) | 0 | 0 | 0 |
| Bone pain, % | 3 (15) | 0 | 0 | 0 |