Univariate patient risk factors for TRALI
| . | No. TRALI/no. without risk factor (%) . | No. TRALI/no. with risk factor (%) . | OR . | Lower 95% CI . | Upper 95% CI . | P . |
|---|---|---|---|---|---|---|
| Medical factors | ||||||
| ≥ 10 units, any component (per unit > 9) | NA | NA | 1.17 | 1.05 | 1.31 | .006 |
| Shock before transfusion | 50/184 (27.2) | 36/69 (56.5) | 4.3 | 2.2 | 8.4 | < .001 |
| Fluid balance pre-TRALI (increment per liter) | NA | NA | 1.17 | 1.08 | 1.28 | < .001 |
| Acute renal failure | 66/213 (31.0) | 23/41 (57.5) | 2.5 | 1.22 | 5.2 | .010 |
| Smoking history (current vs other) | 67/212 (31.6) | 18/36 (50.0) | 1.99 | 0.95 | 4.2 | .07 |
| Peak airway pressure > 30 cmH2O if mechanically ventilated | 73/230 (31.7) | 16/21 (69.6) | 5.6 | 2.1 | 14.9 | < .001 |
| Chronic alcohol abuse | 75/229 (32.8) | 12/18 (88.7) | 3.0 | 1.07 | 8.7 | .04 |
| Severe liver disease | 68/217 (31.3) | 21/36 (58.3) | 2.9 | 1.34 | 6.2 | .007 |
| Surgery type, reference group = no surgery | 1 | |||||
| Liver | 74/233 (31.8) | 15/20 (75.0) | 12.1 | 3.4 | 43.1 | < .001 |
| Spine | 78/230 (33.9) | 11/23 (47.8) | 3.9 | 1.32 | 11.3 | .013 |
| Cardiac | 77/227 (33.9) | 12/26 (46.2) | 3.3 | 1.21 | 9.2 | .02 |
| Vascular | 85/243 (35.0) | 4/10 (40.0) | 2.8 | 0.65 | 12.0 | .17 |
| Other | 67/178 (37.6) | 22/75 (29.3) | 1.40 | 0.69 | 2.8 | .35 |
| Markers of inflammation before transfusion | ||||||
| Log10 IL-6 | NA | NA | 1.65 | 1.04 | 2.6 | .03 |
| Log10 IL-8 | NA | NA | 1.79 | 1.02 | 3.1 | .04 |
| Biologically plausible protective factors | ||||||
| Immunosuppression | 66/166 (39.8) | 22/85 (25.9) | 0.52 | 0.28 | 0.95 | .03 |
| Leukemia or lymphoma | 82/216 (38.0) | 6/36 (16.7) | 0.32 | 0.12 | 0.83 | .02 |
| Pre-TRALI platelet count < 50 × 109/L | 72/176 (40.9) | 10/50 (20.0) | 0.36 | 0.17 | 0.79 | .010 |
| Pre-TRALI WBC count < 0.5 × 109/L | 81/221 (36.7) | 2/15 (13.3) | 0.32 | 0.07 | 1.51 | .15 |
| Patient illness severity as indicated by location of the patient at the time of transfusion* | ||||||
| Intensive care unit (reference group) | 1 | |||||
| Operating room or postoperative recovery unit | 46/157 (29.3) | 43/96 (44.8) | 1.05 | 0.51 | 2.2 | .90 |
| Floor | 75/185 (40.5) | 14/68 (20.6) | 0.22 | 0.09 | 0.54 | < .001 |
| Hematology-oncology floor | 85/229 (37.1) | 4/24 (16.7) | 0.19 | 0.05 | 0.68 | .010 |
| Outpatient | 88/244 (36.1) | 1/9 (11.1) | 0.11 | 0.012 | 1.01 | .05 |
| . | No. TRALI/no. without risk factor (%) . | No. TRALI/no. with risk factor (%) . | OR . | Lower 95% CI . | Upper 95% CI . | P . |
|---|---|---|---|---|---|---|
| Medical factors | ||||||
| ≥ 10 units, any component (per unit > 9) | NA | NA | 1.17 | 1.05 | 1.31 | .006 |
| Shock before transfusion | 50/184 (27.2) | 36/69 (56.5) | 4.3 | 2.2 | 8.4 | < .001 |
| Fluid balance pre-TRALI (increment per liter) | NA | NA | 1.17 | 1.08 | 1.28 | < .001 |
| Acute renal failure | 66/213 (31.0) | 23/41 (57.5) | 2.5 | 1.22 | 5.2 | .010 |
| Smoking history (current vs other) | 67/212 (31.6) | 18/36 (50.0) | 1.99 | 0.95 | 4.2 | .07 |
| Peak airway pressure > 30 cmH2O if mechanically ventilated | 73/230 (31.7) | 16/21 (69.6) | 5.6 | 2.1 | 14.9 | < .001 |
| Chronic alcohol abuse | 75/229 (32.8) | 12/18 (88.7) | 3.0 | 1.07 | 8.7 | .04 |
| Severe liver disease | 68/217 (31.3) | 21/36 (58.3) | 2.9 | 1.34 | 6.2 | .007 |
| Surgery type, reference group = no surgery | 1 | |||||
| Liver | 74/233 (31.8) | 15/20 (75.0) | 12.1 | 3.4 | 43.1 | < .001 |
| Spine | 78/230 (33.9) | 11/23 (47.8) | 3.9 | 1.32 | 11.3 | .013 |
| Cardiac | 77/227 (33.9) | 12/26 (46.2) | 3.3 | 1.21 | 9.2 | .02 |
| Vascular | 85/243 (35.0) | 4/10 (40.0) | 2.8 | 0.65 | 12.0 | .17 |
| Other | 67/178 (37.6) | 22/75 (29.3) | 1.40 | 0.69 | 2.8 | .35 |
| Markers of inflammation before transfusion | ||||||
| Log10 IL-6 | NA | NA | 1.65 | 1.04 | 2.6 | .03 |
| Log10 IL-8 | NA | NA | 1.79 | 1.02 | 3.1 | .04 |
| Biologically plausible protective factors | ||||||
| Immunosuppression | 66/166 (39.8) | 22/85 (25.9) | 0.52 | 0.28 | 0.95 | .03 |
| Leukemia or lymphoma | 82/216 (38.0) | 6/36 (16.7) | 0.32 | 0.12 | 0.83 | .02 |
| Pre-TRALI platelet count < 50 × 109/L | 72/176 (40.9) | 10/50 (20.0) | 0.36 | 0.17 | 0.79 | .010 |
| Pre-TRALI WBC count < 0.5 × 109/L | 81/221 (36.7) | 2/15 (13.3) | 0.32 | 0.07 | 1.51 | .15 |
| Patient illness severity as indicated by location of the patient at the time of transfusion* | ||||||
| Intensive care unit (reference group) | 1 | |||||
| Operating room or postoperative recovery unit | 46/157 (29.3) | 43/96 (44.8) | 1.05 | 0.51 | 2.2 | .90 |
| Floor | 75/185 (40.5) | 14/68 (20.6) | 0.22 | 0.09 | 0.54 | < .001 |
| Hematology-oncology floor | 85/229 (37.1) | 4/24 (16.7) | 0.19 | 0.05 | 0.68 | .010 |
| Outpatient | 88/244 (36.1) | 1/9 (11.1) | 0.11 | 0.012 | 1.01 | .05 |
NA indicates not applicable because the factor is a continuous variable.
May or may not include the first transfusion.