Primary multivariate model of TRALI risk factors: antibodies transfused to the recipient controlled for recipient risk factors
| . | OR . | Lower 95% CI . | Upper 95% CI . | P . |
|---|---|---|---|---|
| Transfusion risk factors among all transfusions to each patient | ||||
| Total quantity of cognate anti-HLA-class II (MFI > 1500) per 10-fold increase | 3.2 | 1.52 | 6.7 | .002 |
| Total volume of anti-HNA positive by GIFT among all units, per 100-mL increase | 1.71 | 1.18 | 2.5 | .004 |
| Recipient risk factors | ||||
| Chronic alcohol abuse | 5.9 | 1.22 | 28.3 | .028 |
| Fluid balance before transfusion (increment per liter) | 1.15 | 1.02 | 1.29 | .024 |
| Peak airway pressure > 30 cmH2O within 12 hours after intubation before transfusion | 3.6 | 1.01 | 13.1 | .048 |
| Shock before transfusion | 4.2 | 1.69 | 10.6 | .002 |
| Current smoker vs never or former smoker | 3.4 | 1.22 | 9.7 | .020 |
| Liver surgery (transplantation) | 6.7 | 1.25 | 35.7 | .027 |
| IL-8 concentration before transfusion, per 10-fold increase | 3.0 | 1.30 | 6.8 | .018 |
| . | OR . | Lower 95% CI . | Upper 95% CI . | P . |
|---|---|---|---|---|
| Transfusion risk factors among all transfusions to each patient | ||||
| Total quantity of cognate anti-HLA-class II (MFI > 1500) per 10-fold increase | 3.2 | 1.52 | 6.7 | .002 |
| Total volume of anti-HNA positive by GIFT among all units, per 100-mL increase | 1.71 | 1.18 | 2.5 | .004 |
| Recipient risk factors | ||||
| Chronic alcohol abuse | 5.9 | 1.22 | 28.3 | .028 |
| Fluid balance before transfusion (increment per liter) | 1.15 | 1.02 | 1.29 | .024 |
| Peak airway pressure > 30 cmH2O within 12 hours after intubation before transfusion | 3.6 | 1.01 | 13.1 | .048 |
| Shock before transfusion | 4.2 | 1.69 | 10.6 | .002 |
| Current smoker vs never or former smoker | 3.4 | 1.22 | 9.7 | .020 |
| Liver surgery (transplantation) | 6.7 | 1.25 | 35.7 | .027 |
| IL-8 concentration before transfusion, per 10-fold increase | 3.0 | 1.30 | 6.8 | .018 |
See Table 8 for numbers of patients for patient risk factors. Numbers of patients who received or did not receive this transfusion risk factor are not available because multiple imputation was used for units with missing data (“Statistical methods: risk factor analysis”). The patient's plasma IL-8 level measured before transfusion was also a predictor of risk in multivariate analysis. Because this variable was missing for 50 patients, reducing the set of analyzed patients to accommodate this variable disrupted the estimates of other risk factors, and so this was not included in the primary model but listed at the end of the table.