Table 1 Characteristics of t(11;14)... | American Society of Hematology

Table 1

Characteristics of t(11;14) breakpoints

	Case	κ/λ	der(14) breakpoints			Nearest CpG	CGC?	Nearest WGCW	der(11) breakpoints
	Case	κ/λ	IgH	CCND1	Distance to CCND1	Nearest CpG	CGC?	Nearest WGCW	CCND1	IgH
CpG breakpoints	W7	κ	J_H5	68 833 760	331 294	1	Y	—	68 833 763	D_H4-17
	W8	κ	J_H6	68 935 608	229 446	0	N	—	68 935 595	D_H3-3
	W18	κ	J_H5	68 940 344	224 710	0	Y	—	68 940 341	D_H3-10
	W15	κ	J_H6	68 957 805*	207 249	0	Y	—	68 957 803	D_H3-3
	W19	κ	J_H4	68 957 805*	207 249	0	Y	—	—	—
	W17	κ	J_H4	68 969 141	195 913	0	Y	—	68 969 139	D_H1–26
	N1	κ	J_H4	68 973 670	191 384	0	Y	—	68 973 668	D_H3-9
	W13	κ	J_H5	68 989 831	175 223	2	Y	—	—	—
	N8	λ	J_H1	69 037 471†	127 583	0	N	—	69 037 466	D_H3-22
	W10	κ	J_H4	69 056 460	108 594	2	N	—	69 056 458	D_H2-21
	N6	κ	J_H4	69 062 733	102 321	1	N	—	69 062 741	D_H3-3
	W11	κ	J_H4	69 082 644	82 410	0	N	—	—	—
	W14	κ	J_H5	69 082 854‡	82 200	2	Y	—	69 082 840	D_H5-5
	W16	κ	J_H4	69 152 043	13 011	4	Y	—	69 152 034	V_H4-34
	N2	λ	J_H4	69 162 371	2 683	0	Y	—	69 162 368	D_H5-12
	W22	κ	J_H1	69 163 029	2 025	0	N	—	69 163 022	D_H3-10
Non-CpG breakpoints	W3	κ	J_H6	68 930 336	234 718	18	—	3	—	—
	N10	—	J_H6	68 999 340	165 714	29	—	14	68 999 340	D_H3-3
	N3	λ	J_H4	69 031 511	133 543	68	—	1	69 031 503	J_H4s§
	W6	λ	J_H6	69 059 199	105 855	98	—	4	—	—
	W4	λ	J_H5	69 065 258	99 796	60	—	16	69 065 237	D_H2-21
	W2	λ	J_H4	69 080 506	85 548	25	—	1	69 080 980	D_H4-23
	W12	λ	J_H6	69 090 218	74 836	167	—	7	69 090 208	D_H2-2
	N4	λ	J_H4	69 091 320	73 734	173	—	10	—	—
	N5	κ	J_H6	69 092 350	72 704	33	—	3	69 092 347	D_H3-3
	N9	—	D_H2-2s§	69 100 683	64 371	10	—	0	69 100 678	D_H2-2
	W5	λ	J_H6	69 123 555	41 499	15	—	12	—	—
	W1	λ	J_H4	69 131 130	33 924	207	—	41	69 131 129	D_H5-18
	W20	κ	J_H4/J_H5‖	69 144 576	20 478	86	—	28	—	—
	W9	λ	J_H4	69 146 211	18 843	106	—	3	69 146 211	D_H4-17
	N7	λ	J_H6	69 146 814	18 240	29	—	36	69 146 895	D_H2-2
	W21	κ	J_H6	69 156 220	8 834	242	—	0	69 156 210	D_H2-2

	Case	κ/λ	der(14) breakpoints			Nearest CpG	CGC?	Nearest WGCW	der(11) breakpoints
	Case	κ/λ	IgH	CCND1	Distance to CCND1	Nearest CpG	CGC?	Nearest WGCW	CCND1	IgH
CpG breakpoints	W7	κ	J_H5	68 833 760	331 294	1	Y	—	68 833 763	D_H4-17
	W8	κ	J_H6	68 935 608	229 446	0	N	—	68 935 595	D_H3-3
	W18	κ	J_H5	68 940 344	224 710	0	Y	—	68 940 341	D_H3-10
	W15	κ	J_H6	68 957 805*	207 249	0	Y	—	68 957 803	D_H3-3
	W19	κ	J_H4	68 957 805*	207 249	0	Y	—	—	—
	W17	κ	J_H4	68 969 141	195 913	0	Y	—	68 969 139	D_H1–26
	N1	κ	J_H4	68 973 670	191 384	0	Y	—	68 973 668	D_H3-9
	W13	κ	J_H5	68 989 831	175 223	2	Y	—	—	—
	N8	λ	J_H1	69 037 471†	127 583	0	N	—	69 037 466	D_H3-22
	W10	κ	J_H4	69 056 460	108 594	2	N	—	69 056 458	D_H2-21
	N6	κ	J_H4	69 062 733	102 321	1	N	—	69 062 741	D_H3-3
	W11	κ	J_H4	69 082 644	82 410	0	N	—	—	—
	W14	κ	J_H5	69 082 854‡	82 200	2	Y	—	69 082 840	D_H5-5
	W16	κ	J_H4	69 152 043	13 011	4	Y	—	69 152 034	V_H4-34
	N2	λ	J_H4	69 162 371	2 683	0	Y	—	69 162 368	D_H5-12
	W22	κ	J_H1	69 163 029	2 025	0	N	—	69 163 022	D_H3-10
Non-CpG breakpoints	W3	κ	J_H6	68 930 336	234 718	18	—	3	—	—
	N10	—	J_H6	68 999 340	165 714	29	—	14	68 999 340	D_H3-3
	N3	λ	J_H4	69 031 511	133 543	68	—	1	69 031 503	J_H4s§
	W6	λ	J_H6	69 059 199	105 855	98	—	4	—	—
	W4	λ	J_H5	69 065 258	99 796	60	—	16	69 065 237	D_H2-21
	W2	λ	J_H4	69 080 506	85 548	25	—	1	69 080 980	D_H4-23
	W12	λ	J_H6	69 090 218	74 836	167	—	7	69 090 208	D_H2-2
	N4	λ	J_H4	69 091 320	73 734	173	—	10	—	—
	N5	κ	J_H6	69 092 350	72 704	33	—	3	69 092 347	D_H3-3
	N9	—	D_H2-2s§	69 100 683	64 371	10	—	0	69 100 678	D_H2-2
	W5	λ	J_H6	69 123 555	41 499	15	—	12	—	—
	W1	λ	J_H4	69 131 130	33 924	207	—	41	69 131 129	D_H5-18
	W20	κ	J_H4/J_H5‖	69 144 576	20 478	86	—	28	—	—
	W9	λ	J_H4	69 146 211	18 843	106	—	3	69 146 211	D_H4-17
	N7	λ	J_H6	69 146 814	18 240	29	—	36	69 146 895	D_H2-2
	W21	κ	J_H6	69 156 220	8 834	242	—	0	69 156 210	D_H2-2

— indicates not applicable.

CCND1 breaks at same CpG.

†

CCND1 break at same CpG as patient HO.⁴

‡

CCND1 break at same CpG as cell line MO1094.⁶

V(D)J signal join (see supplemental Figures 1 and 2).

‖

Non-V(D)J break between J_H4 and J_H5 (see supplemental Figure 1).

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