Impact of BM and PB log reduction and log copy numbers at remission, on relapse risk: unadjusted and adjusted HRs per log decrease
| Measure . | Unadjusted HR per log decrease . | Adjusted HR per log decrease . |
|---|---|---|
| t(8;21) | ||
| Marrow log reduction | 0.36 (0.18-0.74) P = .005 | 0.33 (0.15-0.73) P = .004 |
| Marrow log copy level | 2.27 (1.43-3.58) P = .0005 | 2.84 (1.61-5.00) P = .0002 |
| Blood log reduction | 0.70 (0.45-1.09) P = .12 | 0.65 (0.40-1.08) P = .09 |
| Blood log copy level | 1.46 (1.09-1.97) P = .01 | 1.57 (1.12-2.22) P = .007 |
| inv(16) | ||
| Marrow log reduction | 0.33 (0.16-0.68) P = .003 | 0.30 (0.12-0.77) P = .02 |
| Marrow log copy level | 2.07 (1.20-3.58) P = .009 | 1.78 (0.98-3.21) P = .06 |
| Blood log reduction | 0.40 (0.21-0.76) P = .005 | 0.32 (0.15-0.71) P = .002 |
| Blood log copy level | 2.16 (1.39-3.34) P = .0006 | 2.37 (1.46-3.85) P = .0002 |
| Measure . | Unadjusted HR per log decrease . | Adjusted HR per log decrease . |
|---|---|---|
| t(8;21) | ||
| Marrow log reduction | 0.36 (0.18-0.74) P = .005 | 0.33 (0.15-0.73) P = .004 |
| Marrow log copy level | 2.27 (1.43-3.58) P = .0005 | 2.84 (1.61-5.00) P = .0002 |
| Blood log reduction | 0.70 (0.45-1.09) P = .12 | 0.65 (0.40-1.08) P = .09 |
| Blood log copy level | 1.46 (1.09-1.97) P = .01 | 1.57 (1.12-2.22) P = .007 |
| inv(16) | ||
| Marrow log reduction | 0.33 (0.16-0.68) P = .003 | 0.30 (0.12-0.77) P = .02 |
| Marrow log copy level | 2.07 (1.20-3.58) P = .009 | 1.78 (0.98-3.21) P = .06 |
| Blood log reduction | 0.40 (0.21-0.76) P = .005 | 0.32 (0.15-0.71) P = .002 |
| Blood log copy level | 2.16 (1.39-3.34) P = .0006 | 2.37 (1.46-3.85) P = .0002 |